| Effect of vitamin E supplementation on microalbuminuria, lipid peroxidation and blood prostaglandins in diabetic patients. | |
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MedLine Citation:
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PMID: 15777070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oxidative stress is an important pathogenic factor in the development of diabetic vascular complications. AIMS: To study the effect of vitamin E supplementation on microalbuminuria, plasma levels of malondialdehyde (MLD) and metabolites of prostaglandins TXA2 (TXB2) and PGI2 (6-keto-PGF1alpha) and to evaluate the relation between plasma MLD and thromboxane B2 (TXB2) in diabetic patients. PATIENTS AND METHODS: Diabetic microalbuminuric patients were supplemented with vitamin E 1200 IU daily (EVIT, Rodisma, Germany) and measurements of microalbuminuria, MLD, TXB2 and 6-ketoPGF1alpha were repeated after 4 months of treatment. RESULTS: Vitamin E supplementation lowered microalbuminuria (93.8 +/- 45.6 vs 67.95 +/- 28.4 microg/min, p < 0.05), MLD (0.55 +/- 0.26 vs 0.32 +/- 0.16 micromol/l, p < 0.001) and also TXB2 level (115.14 +/- 22.7 vs 15.32 +/- 14.7 ng/l, p < 0.001) in diabetic microalbuminuric patients. The changes of 6-keto-PGF1alpha after treatment were not significant. CONCLUSIONS: Our results did not show any significant relationship between levels of MLD and TXB2. Vitamin E supplementation significantly lowered microalbuminuria, MLD and TXB2. (Tab. 2, Fig. 2, Ref. 35). |
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Authors:
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E Hirnerova; B Krahulec; L Strbova; A Stecova; J Dekret; A Hajovska; Antwi Ch; A Dukat |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Bratislavské lekárske listy Volume: 105 ISSN: 0006-9248 ISO Abbreviation: Bratisl Lek Listy Publication Date: 2004 |
Date Detail:
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Created Date: 2005-03-21 Completed Date: 2005-04-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0065324 Medline TA: Bratisl Lek Listy Country: Slovakia |
Other Details:
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Languages: eng Pagination: 408-13 Citation Subset: IM |
Affiliation:
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2nd Department of Internal Medicine, University Hospital, Faculty of Medicine, Comenius University, Bratislava, Slovakia. hirnerova@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria* Antioxidants / therapeutic use* Diabetes Mellitus / metabolism* Epoprostenol / blood Humans Lipid Peroxidation* Malondialdehyde / blood Middle Aged Prostaglandins / blood* Thromboxanes / blood Vitamin E / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Prostaglandins; 0/Thromboxanes; 1406-18-4/Vitamin E; 35121-78-9/Epoprostenol; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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