Document Detail

Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults.
MedLine Citation:
PMID:  15296796     Owner:  NLM     Status:  MEDLINE    
In this study we tested the hypothesis that dietary vitamin E supplementation can improve carotid artery elasticity and cardio-vagal baroreflex gain in young, healthy individuals. A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active treatment group received 700 IU/day vitamin E for 1 month. Each subject was studied three times: before, during and 1 month after treatment. Plasma vitamin E levels were determined using high-performance liquid chromatography. Carotid artery diameter was measured by ultrasound and radial artery pressure by tonometry. Baroreflex function was assessed by time and frequency domain spontaneous indices. Plasma vitamin E levels increased by 123%, which was associated with a 20% increase in carotid artery compliance and a 30-60% increase in baroreflex indices. All these changes regressed 1 month after cessation of vitamin E supplementation. Significant correlations were observed across conditions (control, treatment and recovery), among plasma vitamin E concentrations, carotid artery compliance and distensibility values and two of the baroreflex gain indices in the treatment group. Our results demonstrate that vitamin E supplementation can increase carotid artery compliance and baroreflex gain in young, apparently healthy adults.
Péter Studinger; Beatrix Mersich; Zsuzsanna Lénárd; Anikó Somogyi; Mark Kollai
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  113     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-08-06     Completed Date:  2004-11-06     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Faculty of Medicine, H-1446 Budapest, P.O. Box 448, Hungary.
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MeSH Terms
Analysis of Variance
Baroreflex / drug effects*,  physiology
Carotid Artery, Common / drug effects*,  physiology,  ultrasonography
Double-Blind Method
Elasticity / drug effects
Pilot Projects
Vitamin E / pharmacology*
Reg. No./Substance:
1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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