| Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose. | |
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MedLine Citation:
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PMID: 22212745 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: Recent data has shown that vitamin D increases insulin sensitivity; however, there is little evidence about the effects of this treatment on elderly people with impaired fasting glucose. The aim of the present study was to investigate the effect of vitamin D treatment on insulin sensitivity and metabolic parameters in elderly people with impaired fasting glucose. Methods: A total of 28 elderly patients were enrolled into the vitamin D treatment group. The control group included 23 age-, sex- and body mass index-matched elderly participants. The vitamin D treatment group was treated with vitamin D(3) according to serum concentrations of 25(OH)D. Results: With supplementation, 96.0% of patients achieved a mean serum 25(OH)D concentration of 123.2 ± 59.9 nmol/L. After 4.7 ± 2.5 months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group (P = 0.007, P = 0.007, P = 0.037, respectively). Vitamin D treatment significantly increased high-density lipoprotein cholesterol (P = 0.037), but did not cause statistically significant differences in other lipid parameters. Conclusion: We found that vitamin D treatment might modify insulin sensitivity in the elderly with impaired fasting glucose. Geriatr Gerontol Int 2011; ••:••-••. |
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Authors:
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Ilkin Naharci; Ergun Bozoglu; Necmettin Kocak; Suat Doganci; Huseyin Doruk; Muhittin Serdar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
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Title: Geriatrics & gerontology international Volume: - ISSN: 1447-0594 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135738 Medline TA: Geriatr Gerontol Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Japan Geriatrics Society. |
Affiliation:
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Department of Internal Medicine, Division of Geriatrics, and Departments Public Health Cardiovascular Surgery Medical Biochemistry, Gulhane Medical Faculty Training Hospital, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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