| Effect of vitamin D deficiency on mouse mammary gland and milk. | |
| | |
MedLine Citation:
|
PMID: 6693984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lactational performance, milk composition, mammary calcium pools and serum calcium were examined in vitamin D-deficient lactating mice to determine whether the mammary gland is a target organ for vitamin D. CD1 mice were fed vitamin D-deficient or control diets containing 1.2% calcium and 0.5% phosphorus 8-12 weeks prior to breeding. Plasma calcium levels were within normal limits in all mice. Vitamin D deficiency was verified by lack of detectable serum 25-hydroxycholecalciferol. Deficient mice had fewer pups per litter than controls (7.1 +/- 0.5 vs. 8.4 +/- 0.3; P less than 0.05). Pups from vitamin D-deficient and repleted mothers grew at the same rate. Mammary tissue intracellular and extracellular calcium pools, measured by an efflux technique, did not differ in the two groups. Milk samples were collected by suction after injection of 0.1 IU of oxytocin i.p. or anaerobically by a surgical technique. Although protein, Na, K, ionized calcium and pH did not differ, milk from vitamin D-deficient mice had lower lactose (114.6 vs. 135.9 mM; P less than 0.02) and slightly lower calcium (66.8 vs. 75.4 mM; P less than 0.1) concentrations than controls. The data do not demonstrate any direct effects of vitamin D on mammary gland calcium metabolism. |
| | |
Authors:
|
J C Allen |
Related Documents
:
|
7501594 - Effects of dietary calcium and 1,25-dihydroxycholecalciferol on the development of tibi... 10468714 - Lithogenic risk factors in normal black volunteers, and black and white recurrent stone... 1944754 - Enhancement of ionized calcium and 1,25-dihydroxycholecalciferol loss from peritoneal f... 6728794 - Fertility and behavioral responses of roosters to diets differing in protein and calcium. 18950504 - Secular trends in cholesterol lipoproteins and triglycerides and prevalence of dyslipid... 11120444 - A high-beef diet alters protein kinase c isozyme expression in rat colonic mucosa. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of nutrition Volume: 114 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1984 Jan |
Date Detail:
|
Created Date: 1984-03-02 Completed Date: 1984-03-02 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 42-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcium / metabolism Female Growth / drug effects Lactation / drug effects* Lactose / metabolism Mammary Glands, Animal / metabolism, physiopathology* Mice Milk / metabolism* Pregnancy Vitamin D / administration & dosage Vitamin D Deficiency / metabolism, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
HD 14013/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
1406-16-2/Vitamin D; 63-42-3/Lactose; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Failure of dietary leucine to influence the tryptophan-niacin pathway in the chicken.
Next Document: Dietary trilinoelaidate: effects on organ fatty acid composition, prostanoid biosynthesis and platel...