Document Detail

Effect of vitamin D administration during pregnancy on neonatal growth in the rat.
MedLine Citation:
PMID:  2624436     Owner:  NLM     Status:  MEDLINE    
Groups of rats on commercial diet were injected 3,000 IU (group 2) and 7,500 IU (group 3) of vitamin D3 on the 10th day of pregnancy. Compared to control pups (group 1), the pups in group 2 and 3 weighed significantly more on the 10th, 20th and 28th day of age. At 28th day of age, study of the gastrocnemius muscle revealed significantly greater organ weight, protein, DNA and RNA contents, protein/DNA and RNA/DNA ratios in group 2 and 3 pups than in controls. In the liver, whereas all these indices were significantly increased in group 3 pups, only protein/DNA and RNA/DNA ratios were significantly increased in group 2 pups. Brain weight, its RNA content and RNA/DNA ratio were significantly greater in group 2 and 3 pups than in controls. The results suggest that vitamin D administration in pregnancy promotes soft tissue growth in the pups by enhancing cellular proliferation and hypertrophy.
R K Marya; H Lal; K Chugh; A S Saini
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  33     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-29     Completed Date:  1990-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
Department of Physiology, Medical College, Rohtak, India.
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MeSH Terms
Animals, Newborn / growth & development*
Brain / anatomy & histology
Liver / anatomy & histology
Muscles / anatomy & histology
Organ Size / drug effects
Pregnancy, Animal / drug effects*
Rats, Inbred Strains
Vitamin D / administration & dosage,  pharmacology*
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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