Document Detail

Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2max.
MedLine Citation:
PMID:  18427418     Owner:  NLM     Status:  MEDLINE    
AIM: Hypothetically, supplementation with the antioxidant vitamins C could alleviate exercise-induced lipid peroxidation. The purpose of this study was to evaluate the effect of vitamin C supplementation on exercise-induced lipid peroxidation, muscle damage and inflammation. METHODS: Sixteen healthy untrained male volunteers participated in a 30-min exercise at 75% Vo2max. Subjects were randomly assigned to one of two groups: 1) placebo and 2) vitamin C (VC: 1 000 mg vitamin C). Blood samples were obtained prior to supplementation (baseline), 2 h after supplementation (immediately pre-exercise), post-exercise, 2 and 24 h after exercise. Plasma levels of VC, total antioxidant capacity (TAC), creatine kinase (CK), malondealdehyde (MDA), total leukocytes, neutrophils, lymphocytes, interleukin-6 (IL-6) and cortisol were measured. RESULTS: Plasma vitamin C concentrations increased significantly in the VC in response to supplementation and exercise (P<0.05). TAC decreased significantly in Placebo group 24 h after exercise compared to pre-exercise (P<0.05). Although MDA levels were similar between groups at baseline, it increased significantly 2 h after exercise only in the Placebo group (P<0.05). CK increased immediately and 2 h after exercise in both groups and 24 h after exercise only in placebo group compared to pre-exercise (P<0.05). Markers of inflammation (total leukocyte counts, neutrophil counts and IL-6) were increased significantly in response to the exercise (P<0.05). In VC group, there was significant increase in lymphocyte counts immediately after exercise compared with pre-exercise (P<0.05). Serum cortisol concentrations significantly declined after supplementation compared with baseline (P<0.05) as well as declined 2 and 24 h after exercise compared with immediately after exercise in VC group (P<0.05). CONCLUSION: VC supplementation prevented endurance exercise-induced lipid peroxidation and muscle damage but had no effect on inflammatory markers.
B Nakhostin-Roohi; P Babaei; F Rahmani-Nia; S Bohlooli
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  48     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Department of Exercise Physiology, Guilan University, Rasht, Iran
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MeSH Terms
Antioxidants / analysis,  pharmacology*
Ascorbic Acid / blood,  pharmacology*
Double-Blind Method
Exercise Test*
Interleukin-6 / blood
Leukocyte Count
Lipid Peroxidation / drug effects*
Muscle, Skeletal / drug effects*
Oxygen Consumption / physiology
Reg. No./Substance:
0/Antioxidants; 0/Interleukin-6; 50-81-7/Ascorbic Acid

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