Document Detail


Effect of vitamin C on pulmonary hypertension and muscularisation of pulmonary arterioles in broilers.
MedLine Citation:
PMID:  12555895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Three hundred and eighty 1-day-old Arbor Acres broilers were divided into control (A) and experimental (B, C, D, and E) groups. 2. After 14 d of age the experimental groups were subjected to a cool temperature challenge by lowering the temperature 1 to 2 degrees C per day down to 12 degrees C, and maintaining this temperature until 7 weeks of age. 3. At the same time, 1.5 mg/kg 3,3,5-triiodothyronine (T3) was added to the diet of groups D and E, and 500 mg/kg ascorbic acid (vitamin C) to the diet of groups C and E. 4. The incidence of pulmonary hypertension syndrome (PHS), body weight gain and feed intake were measured weekly. Lung and blood samples were collected weekly from 10 birds per group beginning on d 14, and the percentage of thick-walled peripheral lung vessels (% TWPV) and packed cell volume (PCV) were determined. 5. The lower ambient temperature and diets supplemented with T3 increased PHS incidence and % TWPV and decreased body weight gain. 6. There was an increase in PCV after 5 weeks of age under lower ambient temperature 3 and the PCV values 14 were also significantly increased by T3. 7. Vitamin C supplementation reduced PHS incidence and % TWPV but did not change packed cell volume, body, weight gain, feed intake, or feed conversion. 8. It is concluded that vitamin C reduced PHS and the associated muscularisation of pulmonary arterioles induced by exposing broilers to cool environmental temperatures and feeding them with T3.
Authors:
R P Xiang; W D Sun; J Y Wang; X L Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British poultry science     Volume:  43     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-30     Completed Date:  2003-03-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  705-12     Citation Subset:  IM    
Affiliation:
Nanjing Agricultural University, Nanjing, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / drug effects
Ascorbic Acid / pharmacology*
Chickens*
Cold Temperature / adverse effects
Dietary Supplements
Hematocrit
Histocytochemistry / veterinary
Hypertension, Pulmonary / prevention & control,  veterinary*
Lung / blood supply
Poultry Diseases / drug therapy,  metabolism,  prevention & control*
Random Allocation
Triiodothyronine / pharmacology
Chemical
Reg. No./Substance:
50-81-7/Ascorbic Acid; 6893-02-3/Triiodothyronine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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