| Effect of vitamin C on pulmonary hypertension and muscularisation of pulmonary arterioles in broilers. | |
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MedLine Citation:
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PMID: 12555895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Three hundred and eighty 1-day-old Arbor Acres broilers were divided into control (A) and experimental (B, C, D, and E) groups. 2. After 14 d of age the experimental groups were subjected to a cool temperature challenge by lowering the temperature 1 to 2 degrees C per day down to 12 degrees C, and maintaining this temperature until 7 weeks of age. 3. At the same time, 1.5 mg/kg 3,3,5-triiodothyronine (T3) was added to the diet of groups D and E, and 500 mg/kg ascorbic acid (vitamin C) to the diet of groups C and E. 4. The incidence of pulmonary hypertension syndrome (PHS), body weight gain and feed intake were measured weekly. Lung and blood samples were collected weekly from 10 birds per group beginning on d 14, and the percentage of thick-walled peripheral lung vessels (% TWPV) and packed cell volume (PCV) were determined. 5. The lower ambient temperature and diets supplemented with T3 increased PHS incidence and % TWPV and decreased body weight gain. 6. There was an increase in PCV after 5 weeks of age under lower ambient temperature 3 and the PCV values 14 were also significantly increased by T3. 7. Vitamin C supplementation reduced PHS incidence and % TWPV but did not change packed cell volume, body, weight gain, feed intake, or feed conversion. 8. It is concluded that vitamin C reduced PHS and the associated muscularisation of pulmonary arterioles induced by exposing broilers to cool environmental temperatures and feeding them with T3. |
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Authors:
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R P Xiang; W D Sun; J Y Wang; X L Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British poultry science Volume: 43 ISSN: 0007-1668 ISO Abbreviation: Br. Poult. Sci. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-30 Completed Date: 2003-03-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 15740290R Medline TA: Br Poult Sci Country: England |
Other Details:
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Languages: eng Pagination: 705-12 Citation Subset: IM |
Affiliation:
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Nanjing Agricultural University, Nanjing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / drug effects Ascorbic Acid / pharmacology* Chickens* Cold Temperature / adverse effects Dietary Supplements Hematocrit Histocytochemistry / veterinary Hypertension, Pulmonary / prevention & control, veterinary* Lung / blood supply Poultry Diseases / drug therapy, metabolism, prevention & control* Random Allocation Triiodothyronine / pharmacology |
| Chemical | |
Reg. No./Substance:
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50-81-7/Ascorbic Acid; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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