Document Detail

Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study.
MedLine Citation:
PMID:  9631404     Owner:  NLM     Status:  MEDLINE    
A patient-blind study into the effect of a 10-week cessation of long-term vitamin B6 supplementation on B6 status and performance in McArdle's disease is reported. Muscle performance was assessed both subjectively and objectively by an ischaemic fatiguing protocol of the adductor pollicis muscle. Nine weeks after withdrawal of supplementation, vitamin B6 status had changed from adequacy to inadequacy and the force loss during the ischaemic fatiguing protocol had increased at all frequencies studied. The patient reported decreased exercise tolerance after 7 weeks and by the tenth week was experiencing an increase in muscle cramps. Vitamin B6 status and muscle performance may be linked in McArdle's disease and there is potential for enhancement of performance by B6 supplementation.
J Phoenix; P Hopkins; C Bartram; R J Beynon; R C Quinlivan; R H Edwards
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  8     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-28     Completed Date:  1998-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  210-2     Citation Subset:  IM    
Department of Biomolecular Science, UMIST, Manchester, UK.
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MeSH Terms
Dietary Supplements
Glycogen Storage Disease Type V / complications,  drug therapy*,  physiopathology
Middle Aged
Muscle Cramp / etiology,  physiopathology
Muscle, Skeletal / physiopathology
Physical Endurance / physiology
Pyridoxine / administration & dosage,  therapeutic use*
Reg. No./Substance:

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