Document Detail

Effect of vitamin B-6 supplementation on fuels, catecholamines, and amino acids during exercise in men.
MedLine Citation:
PMID:  10188744     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In two separate but identical studies, the effect of vitamin B-6 supplementation was examined on plasma energy substrates, catecholamines, and 13 amino acid concentrations during exercise. METHODS: Eleven trained men performed two separate exhaustive exercise tests at 71.0+/-4.6% VO2max during two separate 9-d controlled diet periods. Exercise test 1 (T1C) occurred following a control diet, and test 2 (T2B6) occurred following a vitamin B-6 supplemented diet (20 mg PN.d(-1)). Blood was drawn pre, during (60 min), post, and post-60 min of exercise, and plasma was analyzed for glucose, lactate, glycerol, free fatty acids (FFA), catecholamines (N = 5), and amino acids (N = 5). RESULTS: Mean FFA concentrations changed over time in both tests (P < 0.001) and were lower in T2B6 compared to T1C at pre (P = 0.03), during (P = 0.05), and post-60 min (P = 0.04) of exercise. Mean lactate, glycerol, and catecholamine concentrations only changed over time (P < 0.0001). The only significant changes in amino acid concentrations were for lower tyrosine (P = 0.007) and methionine (P = 0.03) concentrations in T2B6 relative to TIC at post-60 min of exercise and postexercise, respectively. No differences were observed in exercise times to exhaustion between TIC (108+32.6 min) and T2B6 (109+51.2 min). CONCLUSIONS: These results indicate that vitamin B-6 supplementation can alter plasma FFA and amino acid concentrations during exhaustive endurance exercise without affecting endurance.
R S Virk; N J Dunton; J C Young; J E Leklem
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  31     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-8     Citation Subset:  IM; S    
Department of Nutrition and Food Management, Oregon State University, Corvallis 97331, USA.
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MeSH Terms
Amino Acids / blood*
Catecholamines / blood*
Dietary Supplements*
Energy Metabolism
Exercise / physiology*
Exercise Test
Fatty Acids, Nonesterified / blood
Oxygen Consumption
Pyridoxine / pharmacology*
Reg. No./Substance:
0/Amino Acids; 0/Catecholamines; 0/Fatty Acids, Nonesterified; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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