| Effect of virgin olive oil plus acetylsalicylic acid on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 20079805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aspirin is the most widely used drug for the secondary prevention of ischemic stroke in patients suffering from diabetes mellitus. Moreover virgin olive oil (VOO) administration exerts a neuroprotective effect in healthy rat brain slices. The aim of the present study was to determine the possible influence of VOO administration to streptozotocin-diabetic rats (DR) on the neuroprotective effect of aspirin in rat brain. DR were treated during 3 months with saline, aspirin (2mg/kg/day p.o.), VOO (0.5 mL/kg/day p.o.) or its association; a control normoglycemic group was treated with saline. Brain slices were subjected to oxygen-glucose deprivation before a reoxygenation period. All the treatments significantly reduced lactate dehydrogenase LDH efflux after reoxygenation (-54.1% for aspirin, -51.3% for VOO and -72.9% for aspirin plus VOO). Lipid peroxides in brain slices were also reduced after the treatment with aspirin (-17.90%), VOO (-37.3%) and aspirin plus VOO (-49.2%). Production of nitric oxide after reoxygenation was inhibited by all the treatments (-46.5% for ASA, -48.2% for VOO and -75.8% for ASA plus VOO). The activity of the inducible isoform (iNOS) was inhibited by the three types of treatment (-31.8% for ASA, -29.1% for VOO and -56.0% for ASA plus VOO). The main conclusion of our study is that daily oral administration of VOO to diabetic rats may be a natural way to increase the neuroprotective effect of aspirin in diabetic animals. |
| | |
Authors:
|
Jos? Pedro De La Cruz; Sergio Del R?o; Mar?a Monsalud Arrebola; Juan Antonio L?pez-Villodres; Nuria Jebrouni; Jos? Antonio Gonz?lez-Correa |
Related Documents
:
|
2717785 - A substance resembling somatomedin c in the american cockroach. 19022375 - A look inside the diabetic brain: contributors to diabetes-induced brain aging. 2234505 - Tetrahydroaminoacridine increases acetylcholine synthesis and glucose oxidation by mous... 2083575 - Influence of microinjection of insulin into the ventromedial hypothalamus on acetate me... 16700635 - Knowledge of heart disease risk in a multicultural community sample of people with diab... 12053095 - Inhibin b levels in adolescents and young adults with type 1 diabetes. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-15 |
Journal Detail:
|
Title: Neuroscience letters Volume: 471 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 89-93 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Laboratorio de Investigaciones Antitromb?ticas e Isquemia Tisular (LIAIT), Department of Pharmacology and Therapeutics, School of Medicine, University of M?laga, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aspirin / pharmacology* Brain / drug effects*, metabolism Diabetes Mellitus, Experimental / complications Diabetes Mellitus, Type 1 / complications* Hypoxia, Brain / etiology, metabolism, prevention & control* L-Lactate Dehydrogenase / metabolism Lipid Peroxidation Male Neuroprotective Agents / pharmacology* Nitric Oxide / biosynthesis Nitric Oxide Synthase Type II / antagonists & inhibitors Plant Oils / pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Neuroprotective Agents; 0/Plant Oils; 10102-43-9/Nitric Oxide; 50-78-2/Aspirin; 8001-25-0/olive oil; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.14.13.39/Nitric Oxide Synthase Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gesture influences the processing of figurative language in non-native speakers: ERP evidence.
Next Document: Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer t...