Document Detail


Effect of vertebroplasty on pain relief, quality of life, and the incidence of new vertebral fractures: A 12-month randomized follow-up, controlled trial.
MedLine Citation:
PMID:  22513649     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Uncertainty regarding the benefits of vertebroplasty (VP) for the treatment of acute osteoporotic vertebral fractures has recently arisen. A prospective, controlled, randomized single-center trial (ClinicalTrials.gov registration number NCT00994032) was designed to compare the effects of VP versus conservative treatment on the quality of life and pain in patients with painful osteoporotic vertebral fractures, new fractures and secondary adverse effects were also analyzed during a 12-month follow-up period. A total of 125 patients were randomly assigned to receive conservative treatment or VP. The primary end point was to compare the evolution of the quality of life (Quality of Life Questionnaire of the European Foundation for Osteoporosis [Qualeffo-41] and pain (Visual Analogue Scale [VAS]) during a 12 month follow-up. Secondary outcomes included comparison of analgesic consumption, clinical complications, and radiological vertebral fractures at the same time points. Both arms showed significant improvement in VAS scores at all time points, with greater improvement (p = 0.035) in the VP group at the 2-month follow-up. Significant improvement in Qualeffo total score was seen in the VP group throughout the study, whereas this was not seen in the conservative treatment arm until the 6-month follow-up. VP treatment was associated with a significantly increased incidence of vertebral fractures (odds ratio [OR], 2 · 78; 95% confidence interval [CI], 1.02-7.62, p = 0.0462). VP and conservative treatment are both associated with significant improvement in pain and quality of life in patients with painful osteoporotic vertebral fractures over a 1-year follow-up period. VP achieved faster pain relief with significant improvement in the pain score at the 2-month follow-up but was associated with a higher incidence in vertebral fractures. © 2012 American Society for Bone and Mineral Research.
Authors:
Jordi Blasco; Angeles Martinez-Ferrer; Juan Macho; Luis San Roman; Jaume Pomés; Josep Carrasco; Ana Monegal; Nuria Guañabens; Pilar Peris
Related Documents :
24494689 - The neurobiology of skeletal pain.
22672919 - Guided imagery for non-musculoskeletal pain: a systematic review of randomized clinical...
22430659 - Treatment of functional chest pain with antidepressants: a meta-analysis.
24351159 - Pain, masticatory performance and swallowing threshold in orthodontic patients.
23991279 - Piezosurgery vs high speed rotary handpiece: a comparison between the two techniques in...
22558609 - Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of ...
7247269 - Intrathoracic manifestations of amoebiasis.
11915639 - Clinical treatment evaluations of a new topical oral medication.
1743179 - The objective measurement of pain using a motor-performance task.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  27     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1159-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Bone and Mineral Research.
Affiliation:
Neurointerventional Department, Centre Diagnòstic per la Imatge, Hospital Clinic, Barcelona, Spain. jblasco@clinic.ub.es.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I ...
Next Document:  Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Par...