Document Detail

Effect of veratridine injected into the aortic root on resistance and capacitance in the abdominal circulation in anaesthetized dogs.
MedLine Citation:
PMID:  3786659     Owner:  NLM     Status:  MEDLINE    
In dogs anaesthetized with chloralose, cardiac receptors were stimulated by injections of veratridine into the aortic root and the effects studied on resistance and capacitance in the vascularly isolated and perfused abdominal circulation. Unless carotid sinus pressure was high, veratridine injections consistently resulted in dilatation of resistance and capacitance vessels. However, at high carotid pressures, the resistance response to veratridine was inhibited and the capacitance response was usually reversed. These results indicate that stimulation of cardiac receptors can affect resistance and capacitance in the abdominal circulation. Further experiments are required to evaluate the physiological role of these responses.
R Hainsworth; K H McGregor; R Ford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Quarterly journal of experimental physiology (Cambridge, England)     Volume:  71     ISSN:  0144-8757     ISO Abbreviation:  Q J Exp Physiol     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-21     Completed Date:  1987-01-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8206873     Medline TA:  Q J Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  589-98     Citation Subset:  IM    
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MeSH Terms
Abdomen / blood supply*
Anesthesia, General
Blood Pressure / drug effects
Carotid Sinus / drug effects,  physiology
Cold Temperature
Physiology / instrumentation
Vagus Nerve / physiology
Vascular Resistance / drug effects*
Veratridine / administration & dosage*,  pharmacology
Veratrine / analogs & derivatives*
Reg. No./Substance:
62-59-9/Veratrine; 71-62-5/Veratridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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