Document Detail


Effect of verapamil inhalation on bronchial asthma.
MedLine Citation:
PMID:  2307645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of inhaled verapamil 20 mg on pulmonary functions and arterial blood gases in 15 patients with extrinsic bronchial asthma was studied in single-blind fashion. A significant decrease (p less than 0.05) in airway resistance and a significant increase (p less than 0.01) in specific conductance was observed after verapamil inhalation. A small increase (p less than 0.1) was observed in forced vital capacity and peak expiratory flow rate after verapamil inhalation; however, this was not statistically significant. None of the parameters of pulmonary function tests showed a significant change after normal saline inhalation. A significant fall in PaO2 (p less than 0.05) and PaCO2 (p less than 0.05) was noted after normal saline inhalation. PaCO2 showed a significant fall (p less than 0.01) after verapamil inhalation. Alveolar arterial oxygen gradient P(A-a)O2 widened significantly (p less than 0.001) after normal saline inhalation. A larger dose (20 mg) of verapamil inhalation produces a significant bronchodilator effect on large airways, but does not produce a significant change in arterial oxygen tension from the baseline value in patients with bronchial asthma.
Authors:
S K Sharma; J N Pande
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  27     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-11     Completed Date:  1990-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Adult
Asthma / blood,  drug therapy*,  physiopathology
Blood Gas Analysis
Female
Humans
Male
Respiratory Function Tests
Verapamil / therapeutic use*
Chemical
Reg. No./Substance:
52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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