Document Detail

Effect of ventromedial hypothalamic stimulation on blood flow of brown adipose tissue in rats.
MedLine Citation:
PMID:  3684509     Owner:  NLM     Status:  MEDLINE    
The changes in regional blood flows to the rat's interscapular brown adipose tissue and several other tissues during electrical stimulation of the ventromedial hypothalamus (VMH) were studied using radioactively labelled microspheres. Measurement of blood flow was carried out, along with monitoring heart rate, under anesthesia and at thermoneutrality. During VMH stimulation the heart rate was clearly augmented and cardiac output increased about 45%. Regional blood flows were significantly increased in response to VMH stimulation in interscapular brown adipose tissue, adrenal glands, diaphragm and gastrocnemius muscles. The response of interscapular brown adipose tissue was the most prominent (approx. fifty-fold increase). Blood flows tended to decrease in spleen, lungs and kidneys during VMH stimulation, but did not change in liver or in other visceral organs. These observations suggest that the VMH is concerned with the regulation of regional blood flow to brown adipose tissue and contributes to thermogenesis in this tissue.
M Iwai; N S Hell; T Shimazu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  410     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-01-15     Completed Date:  1988-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  IM    
Department of Medical Biochemistry, School of Medicine, Ehime University, Japan.
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MeSH Terms
Adipose Tissue, Brown / blood supply*
Cobalt Radioisotopes / diagnostic use
Electric Stimulation
Heart Rate
Hypothalamus, Middle / physiology*
Rats, Inbred Strains
Regional Blood Flow
Strontium Radioisotopes / diagnostic use
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Strontium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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