Document Detail


Effect of ventilation on cerebral oxygenation during exercise: insights from canonical correlation.
MedLine Citation:
PMID:  19429529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested hypothesis that cerebral deoxygenation near maximal exercise intensity is mediated by hyperventilation, via hypocapnia-induced reductions in cerebral blood flow, by utilizing canonical correlation analysis (CCA) to determine the relative influence of cardiopulmonary changes on cerebral oxygenation, as assessed by near infrared spectroscopy (NIRS). Twenty-three subjects performed incremental exercise tests under normoxic and hypoxic conditions. Changes in ventilation (V (E)) were strongly correlated with end-tidal CO(2) (P(ET)(CO)(2)) and NIRS after the respiratory compensation point (RCP) (r(2)>0.97). However, in contrast to our expectations, CBF velocity (CBFv) shared the least amount of variance with NIRS measurements (r(2)<0.56) and the reduction in CBFv was not accompanied by a reduction in cerebral blood volume. These results demonstrate that while cerebral deoxygenation was associated with hyperventilation, it was not solely explained by hypocapnia-induced reductions in CBFv. CCA revealed that a relative increase in the venous contribution to NIRS explained a larger amount of variation in cerebral oxygenation than reductions CBFv.
Authors:
Martin Heine; Andrew W Subudhi; Robert C Roach
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-03-05
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  166     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-07     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Affiliation:
Altitude Research Center, University of Colorado, Denver, CO, United States.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / physiopathology
Cerebrovascular Circulation / physiology*
Double-Blind Method
Exercise / physiology*
Female
Humans
Male
Oxygen Consumption / physiology
Pulmonary Ventilation / physiology*
Spectroscopy, Near-Infrared / methods
Tidal Volume
Ventilators, Mechanical
Young Adult
Grant Support
ID/Acronym/Agency:
HL-070362/HL/NHLBI NIH HHS; R01 HL070362-01/HL/NHLBI NIH HHS; R01 HL070362-02/HL/NHLBI NIH HHS; R01 HL070362-03/HL/NHLBI NIH HHS; R01 HL070362-04/HL/NHLBI NIH HHS; R01 HL070362-05/HL/NHLBI NIH HHS
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