Document Detail


Effect of vasoactive intestinal polypeptide on cerebral blood flow in the goat.
MedLine Citation:
PMID:  7304209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of vasoactive intestinal polypeptide (VIP) on the cerebral blood flow was investigated in the goat. An electromagnetic flow probe was placed around the internal maxillary artery for continuous measurement of ipsilateral blood flow. Intraarterial injection of VIP resulted in a dose-dependent increase in the cerebral blood flow. The effect was not antagonized by any of the antagonists atropine, propranolol, phentolamine and naloxone administered intraarterially 1 min before VIP. It is discussed that VIP may play a physiological role in the local blood flow regulation in the CNS.
Authors:
J J Larsen; V Boeck; B Ottesen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  111     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Cerebrovascular Circulation / drug effects*
Dose-Response Relationship, Drug
Gastrointestinal Hormones / physiology*
Goats / physiology*
Naloxone / pharmacology
Phentolamine / pharmacology
Propranolol / pharmacology
Vasoactive Intestinal Peptide / physiology*
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 37221-79-7/Vasoactive Intestinal Peptide; 465-65-6/Naloxone; 50-60-2/Phentolamine; 51-55-8/Atropine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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