Document Detail

Effect of various hypotensive agents on locomotor activity and blood pressure of rats.
MedLine Citation:
PMID:  2132423     Owner:  NLM     Status:  MEDLINE    
The effect of various hypotensive agents were simultaneously tested on locomotor activity and blood pressure of unanaesthetised (conscious) rats. The agents viz clonidine, prazosin, furosemide and hexamethonium were found to reduce significantly the locomotor activity as well as blood pressure, 30 min post administration. Phenoxybenzamine and alpha-methyldopa produced similar type of effect but after 60 and 120 min post administration respectively. Aminophylline and propranolol failed to reduce locomotor activity as well as blood pressure, 60 and 90 min post administration. The findings of the present study are strongly indicative that hypotensive agents reduce locomotor activity and that the reduction is sequel to the fall in blood pressure.
P P Singh; A Y Junnarkar; R K Varma; G P Thomas; R M Tripathi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Materia medica Polona. Polish journal of medicine and pharmacy     Volume:  22     ISSN:  0025-5246     ISO Abbreviation:  Mater Med Pol     Publication Date:    1990 Jul-Sep
Date Detail:
Created Date:  1992-01-14     Completed Date:  1992-01-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0236526     Medline TA:  Mater Med Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  176-8     Citation Subset:  IM    
Department of Pharmacology, IDPL Research Centre, Hyderabad, India.
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MeSH Terms
Antihypertensive Agents / toxicity*
Blood Pressure / drug effects*
Injections, Intraperitoneal
Locomotion / drug effects*
Rats, Inbred Strains
Reg. No./Substance:
0/Antihypertensive Agents

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