Document Detail


Effect of the variation in the ambient moisture on the compaction behavior of powder undergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules.
MedLine Citation:
PMID:  16136545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effect of variation in the ambient moisture levels on the compaction behavior of a 10% acetaminophen (APAP) powder blend in microcrystalline cellulose (MCC) powder was studied by comparing the physical and mechanical properties of ribbons prepared by roller compaction with those of simulated ribbons, i.e., tablets prepared under uni-axial compression. Relative density, moisture content, tensile strength, and Young's modulus were used as key compact properties for comparison. Moisture was found to facilitate the particle rearrangement of both, the APAP and the MCC particles, as well as the deformation of the MCC particles. The tensile strength of the simulated ribbons also showed an increase with increasing moisture content. An interesting observation was that the tensile strength of the roller compacted samples first increased and then decreased with increasing moisture content. Variation in the ambient moisture during roller compaction was also found to influence the characteristics of tablets produced from the granules obtained post-milling the ribbons. A method to study this influence is also reported.
Authors:
Abhay Gupta; Garnet E Peck; Ronald W Miller; Kenneth R Morris
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  94     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-06     Completed Date:  2006-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2314-26     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 Wiley-Liss, Inc. and the American Pharmacists Association
Affiliation:
Department of Industrial and Physical Pharmacy, Purdue University School of Pharmacy, West Lafayette, Indiana 47907-2091, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / chemistry
Cellulose / chemistry
Drug Compounding*
Excipients / chemistry
Humidity
Particle Size
Porosity
Powders*
Solubility
Tablets*
Tensile Strength
Water / chemistry*
Chemical
Reg. No./Substance:
0/Excipients; 0/Powders; 0/Tablets; 0/microcrystalline cellulose; 103-90-2/Acetaminophen; 7732-18-5/Water; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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