Document Detail

Effect of valsartan on renal handling of uric acid in healthy subjects.
MedLine Citation:
PMID:  10858975     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of valsartan on renal handling of uric acid in healthy subjects. METHODS: A randomized, single-blind, placebo-controlled clinical trial was performed in twelve healthy volunteers. Six received a morning dose of valsartan 80 mg orally during 14 to 21 days and the other six received placebo. Before and after valsartan or placebo, clearance, fractional excretion and excretion uric acid rates were calculated. Presecretory reabsorption, tubular secretion and postsecretory reabsorption of uric acid were assessed by pharmacological tests using pyrazinamide or probenecid. RESULTS: There were no differences in clearance, fractional excretion and excretion uric acid rates with valsartan and placebo. Valsartan did not affect presecretory reabsorption (p = 0.92), tubular secretion (p = 0.62) or postsecretory reabsorption (p = 0.52) of uric acid. CONCLUSION: Valsartan did not significantly affect renal handling of uric acid in healthy subjects.
M Gonz?lez-Ortiz; J M Mora-Mart?nez; E Mart?nez-Abundis; B R Balc?zar-Mu?oz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nephrology     Volume:  13     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-10-26     Completed Date:  2000-10-26     Revised Date:  2010-05-31    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  126-8     Citation Subset:  IM    
Medical Research Unit in Clinical Epidemiology, West National Medical Center, Mexican Institute of Social Security, Guadalajara City, Jalisco.
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MeSH Terms
Kidney / drug effects*,  metabolism*
Single-Blind Method
Tetrazoles / pharmacology*
Uric Acid / metabolism*
Valine / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Tetrazoles; 137862-53-4/valsartan; 69-93-2/Uric Acid; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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