| Effect of vagotomy on secretin release in man. | |
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MedLine Citation:
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PMID: 1218818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The release of secretin by intraduodenal acid has been measured by means of a highly sensitive radioimmunoassay in 12 normal subjects, 23 duodenal ulcer patients, and 14 vagotomized patients (6 TV + P; 4 SV + P;4 HSV). A highly significant response occurred in all three groups. There was no significant difference between the groups either in the magnitude or timing of this response, though the absolute values for pre-stimulation and peak secretin were significantly smaller in preoperative duodenal ulcer patients than in either the normal subjects or the vagotomized patients. The secretin response was similar after truncal, selective, and highly selective vagotomy. These results suggest that secretin release is not dependent on intact vagal innervation of the small intestine in man. |
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Authors:
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A S Ward; S R Bloom |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gut Volume: 16 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-05-25 Completed Date: 1976-05-25 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 951-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Duodenum / physiopathology Female Gastric Juice / drug effects, secretion Humans Hydrochloric Acid / administration & dosage Male Middle Aged Pentagastrin / pharmacology Secretin / blood, secretion* Vagotomy* |
| Chemical | |
Reg. No./Substance:
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1393-25-5/Secretin; 5534-95-2/Pentagastrin; 7647-01-0/Hydrochloric Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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