| Effect of vaginal metronidazole + miconazole treatment during pregnancy for gestational age and birth weight in a population-based study. | |
MedLine Citation:
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PMID: 16001192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the study was to check the effect of the combination of metronidazole and miconazole (M+M) for the prevention of sexually transmitted infections/disorders related preterm delivery/birth. Antiprotozoal vaginal metronidazole was not able to prevent preterm birth, while the antifungal topical miconazole use showed some reduction in preterm birth in our previous studies. The population-based large control (without any defects) data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities was used for the evaluation of the combination of M+M for birth outcomes. Of 38,151 controls, 846 (2.2%) had treatment with vaginal tablet of M+M for vaginal infections. The prevalence of preterm birth was 9.5% after this treatment compared with the 9.2% of preterm birth in the untreated group. Thus the combination of M+M was not able to reduce the preterm birth associated with vulvovaginal infections/disorders. |
Authors:
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Zoltán Kazy; Erzsébet Puhó; Andrew E Czeizel |
Publication Detail:
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Type: Journal Article Date: 2005-10-13 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 272 ISSN: 0932-0067 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-17 Completed Date: 2006-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 294-7 Citation Subset: IM |
Affiliation:
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Foundation for the Community Control of Hereditary Diseases, Trkvsz lejt 32., Budapest, 1026, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Adult Antifungal Agents / administration & dosage* Birth Weight Case-Control Studies Female Gestational Age Humans Hungary Infant, Newborn Infant, Premature Metronidazole / administration & dosage* Miconazole / administration & dosage* Obstetric Labor, Premature / microbiology, prevention & control* Pregnancy Prospective Studies Retrospective Studies Sexually Transmitted Diseases / drug therapy*, microbiology Vaginal Diseases / drug therapy*, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 22916-47-8/Miconazole; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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