Document Detail

Effect of vaginal metronidazole + miconazole treatment during pregnancy for gestational age and birth weight in a population-based study.
MedLine Citation:
PMID:  16001192     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to check the effect of the combination of metronidazole and miconazole (M+M) for the prevention of sexually transmitted infections/disorders related preterm delivery/birth. Antiprotozoal vaginal metronidazole was not able to prevent preterm birth, while the antifungal topical miconazole use showed some reduction in preterm birth in our previous studies. The population-based large control (without any defects) data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities was used for the evaluation of the combination of M+M for birth outcomes. Of 38,151 controls, 846 (2.2%) had treatment with vaginal tablet of M+M for vaginal infections. The prevalence of preterm birth was 9.5% after this treatment compared with the 9.2% of preterm birth in the untreated group. Thus the combination of M+M was not able to reduce the preterm birth associated with vulvovaginal infections/disorders.
Zoltán Kazy; Erzsébet Puhó; Andrew E Czeizel
Publication Detail:
Type:  Journal Article     Date:  2005-10-13
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  272     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  294-7     Citation Subset:  IM    
Foundation for the Community Control of Hereditary Diseases, Trkvsz lejt 32., Budapest, 1026, Hungary.
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MeSH Terms
Administration, Intravaginal
Antifungal Agents / administration & dosage*
Birth Weight
Case-Control Studies
Gestational Age
Infant, Newborn
Infant, Premature
Metronidazole / administration & dosage*
Miconazole / administration & dosage*
Obstetric Labor, Premature / microbiology,  prevention & control*
Prospective Studies
Retrospective Studies
Sexually Transmitted Diseases / drug therapy*,  microbiology
Vaginal Diseases / drug therapy*,  microbiology
Reg. No./Substance:
0/Antifungal Agents; 22916-47-8/Miconazole; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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