| Effect of use of mitomycin C on the outcome of Choanal atresia repair. | |
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MedLine Citation:
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PMID: 17914516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effectiveness of topical mitomycin C (MMC) on outcome of endoscopic repair of choanal atresia (CA) in cases that had never had this operation and when nasal stent was not used. METHODS: Endoscopic repair of CA was performed in 20 children at King Abdul-Aziz University Hospital, Riyadh, Kingdom of Saudi Arabia between January 1999 and October 2005. Intra-operative application of topical MMC (0.4 mg/mL for 4 minutes) was carried out in 13 children, and 7 children did not receive MMC. The follow-up period ranged between 9 months and 6 years. The association between the 2 categorical variables was investigated using Fisher's exact test. RESULTS: Sixty-nine percent of the cases receiving MMC had a successful outcome compared with 57% of non-MMC cases, however, the difference was not statistically significant (p=0.230). In unilateral CA, 70% of those who received MMC had a successful outcome compared with 60% of those who did not; again the difference was not statistically significant (p=0.566). Successful outcome was considered when the posterior choana was patent during the successive follow up, without the need for revision surgeries. CONCLUSION: We did not demonstrate a statistically significant difference between the percentages of children treated with MMC versus no-MMC who remained patent after surgery. |
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Authors:
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Ahmed Y Al-Ammar |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Saudi medical journal Volume: 28 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-04 Completed Date: 2008-02-27 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 1537-40 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology Head and Neck Surgery, King Abdul-Aziz University Hospital, Riyadh, Kingdom of Saudi Arabia. ahmedalammar@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antibiotics, Antineoplastic / therapeutic use* Child Child, Preschool Choanal Atresia / drug therapy*, surgery* Endoscopy* Female Humans Infant Infant, Newborn Male Mitomycin / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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