Document Detail

Effect of ursodeoxycholic acid (UDCA) on pancreatic enzyme secretion and gallbladder emptying.
MedLine Citation:
PMID:  2315289     Owner:  NLM     Status:  MEDLINE    
We have used a duodenal perfusion technique to study the effect of chronic administration of ursodeoxycholic acid (UDCA) on postprandial pancreatic enzyme secretion and gallbladder emptying. Duodenal output and hepatic secretion rate of bile acid were also measured. Six gallstone subjects were studied during an evening meal and an overnight fast before and during UDCA administration (675 mg/day for 6 weeks). During the first postprandial hour, the duodenal trypsin output was reduced from 253 to 164 IU/kg/h (p less than 0.05), and mean gallbladder ejection fraction from 38 to 20% (p less than 0.05). The peak response to the meal was delayed from 30 to 50 min for trypsin output (NS) and from 25 to 45 min for gallbladder ejection fraction (p less than 0.05). Area under the curve during the first postprandial hour was decreased for trypsin output from 225 to 119 IU/kg (p less than 0.025), and for gallbladder ejection fraction from 43 to 19% (NS); but areas for the second postprandial hour were increased, so that total values were unchanged. We conclude that the pattern of response for both end organs during chronic UDCA is better described as an attenuated response to food, rather than as a simple reduction in response; and that, since the effects were unaccompanied by any quantitative changes in hepatic bile acid secretion rate, they were probably mediated via the qualitative change in biliary bile acid composition known to accompany chronic UDCA administration.
A Lanzini; N Hall; D Facchinetti; T C Northfield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pancreas     Volume:  5     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  128-35     Citation Subset:  IM    
Department of Medicine 2, St. George's Hospital Medical School, London, U.K.
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MeSH Terms
Bile Acids and Salts / secretion
Deoxycholic Acid / analogs & derivatives*
Duodenum / enzymology,  secretion
Gallbladder / drug effects*
Liver / secretion
Middle Aged
Pancreas / drug effects*,  enzymology,  secretion
Reproducibility of Results
Trypsin / secretion
Ursodeoxycholic Acid / pharmacology*
Reg. No./Substance:
0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid; 83-44-3/Deoxycholic Acid; EC

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