Document Detail

Effect of urea and pantothenol on the permeation of progesterone through excised rat skin from polymer matrix systems.
MedLine Citation:
PMID:  11247536     Owner:  NLM     Status:  MEDLINE    
Standard in vitro permeation experiments, using excised rat skin, were carried out to establish the release profile and permeation behavior of progesterone from polymethacrylate (PMA), polyvinylpyrrolidon (PVP), and polyvinylalcohol (PVA) transdermal systems. Data obtained show significant differences in release characteristics from each polymer systems. The greatest amount of progesterone was released from the PVA system. The influence of urea and pantothenol on progesterone release was also investigated. Release data were compared with the permeation rates of progesterone across excised rat skin. The highest permeation rates were measured from PVA matrices containing 5% urea (860 +/- 138 micrograms/cm2; cumulative amount permeated in 24 hr) and from PVP matrices containing 6% pantothenol (660 +/- 73 micrograms/cm2; cumulative amount permeated in 24 hr). A good correlation between release and permeation data was found with the polymer matrices; however, this was not the case when additives were included.
C Valenta; T Dabic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  27     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, A-1090 Vienna, Austria.
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MeSH Terms
Administration, Cutaneous
Culture Techniques
Pantothenic Acid / analogs & derivatives*,  pharmacology*
Progesterone / administration & dosage,  pharmacokinetics*
Skin / drug effects*
Urea / pharmacology*
Reg. No./Substance:
0/Polymers; 57-13-6/Urea; 57-83-0/Progesterone; 62507-76-0/dexpanthenol; 79-83-4/Pantothenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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