Document Detail

Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication.
MedLine Citation:
PMID:  18226561     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the effects of exercise training on levels of circulating biomarkers associated with the progression of atherosclerosis and risk of cardiovascular events in patients with intermittent claudication. METHODS: Circulating levels of soluble adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), high sensitivity C-reactive protein (hs-CRP) and stress proteins (Hsp60 and Hsp70) in patients randomised to a 24-week programme of arm- or leg-cranking exercise were compared with those in usual care controls. RESULTS: Arm and leg exercise similarly improved lower-limb aerobic exercise capacity (20% vs 19%, respectively; P<0.001) and maximum walking distance (30% vs 35%, respectively; P<0.001). Improvements in training limb-specific peak oxygen consumption were attenuated for patients in the highest vs lowest quartile for circulating sVCAM-1 levels at baseline (3% vs 25% respectively, P<0.001). Although circulating hs-CRP levels tended to be lower in the arm-cranking group (-1.55 [95% CI: -1.06 to -2.26]mgl(-1)), exercise training had no effect on circulating levels of soluble adhesion molecules or stress proteins. CONCLUSIONS: These findings suggest that high levels of circulating sVCAM-1 are associated with an attenuated exercise training response and that arm-cranking exercise may provide an effective stimulus for evoking systemic anti-inflammatory adaptations in patients with intermittent claudication.
J M Saxton; I Zwierska; K Hopkinson; E Espigares; S Choksy; S Nawaz; R Walker; A G Pockley
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-01-15
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  35     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  607-13     Citation Subset:  IM    
Centre for Sport and Exercise Science, Sheffield Hallam University, Collegiate Crescent Campus, Sheffield S10 2BP, UK.
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MeSH Terms
Atherosclerosis / blood
Biological Markers / blood
C-Reactive Protein / analysis*
Cardiovascular Diseases / epidemiology
Cell Adhesion Molecules / blood*
Chaperonin 60 / blood
Disease Progression
E-Selectin / blood
Exercise Therapy*
HSP70 Heat-Shock Proteins / blood
Heat-Shock Proteins / blood*
Intercellular Adhesion Molecule-1 / blood
Intermittent Claudication / blood*,  therapy*
Lower Extremity
Middle Aged
Risk Factors
Upper Extremity
Vascular Cell Adhesion Molecule-1 / blood
Reg. No./Substance:
0/Biological Markers; 0/Cell Adhesion Molecules; 0/Chaperonin 60; 0/E-Selectin; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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