Document Detail


Effect of unilateral vesicoureteric reflux on renal growth and the uptake of 99mTc DMSA by the kidney. An experimental study in the minipig.
MedLine Citation:
PMID:  2540868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of unilateral vesicoureteric reflux (VUR) on renal growth and the uptake of 99mTc DMSA by the kidney has been investigated in a 2-kidney model in the growing minipig over a period of approximately 5 months. Animals with reflux in association with low voiding pressures and normal bladder function (n = 5), as well as those with raised voiding pressures and abnormal bladder function (n = 7), were investigated with appropriate non-refluxing controls (n = 12). Urinary infection and renal scarring were avoided since these factors may affect kidney function and growth independently. Statistical tests of difference failed to demonstrate any effect of VUR on renal growth or renal uptake of 99mTc DMSA even in the presence of elevated voiding pressures and abnormal detrusor function.
Authors:
M L Godley; R A Risdon; P G Ransley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of urology     Volume:  63     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-15     Completed Date:  1989-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  340-7     Citation Subset:  IM    
Affiliation:
Institute of Child Health, London.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Female
Kidney / growth & development,  physiopathology*,  radionuclide imaging
Male
Organometallic Compounds / diagnostic use*
Succimer / diagnostic use*
Sulfhydryl Compounds / diagnostic use*
Swine
Swine, Miniature
Technetium / diagnostic use*
Technetium Tc 99m Dimercaptosuccinic Acid
Vesico-Ureteral Reflux / physiopathology*,  radionuclide imaging
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 0/Sulfhydryl Compounds; 304-55-2/Succimer; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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