| Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally. | |
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MedLine Citation:
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PMID: 12857050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before right adrenalectomy revealed elevated serum concentrations of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) both systemically and in the adrenal veins bilaterally. Histopathological and immunohistochemical analyses of the surgical specimen demonstrated adrenal hyperplasia of outer fasciculata cells, and the presence of cystic mass. The adrenalectomy ameliorated her blood pressure (BP) from 156/96 mmHg to 148/87 mmHg with a concomitant increase of serum potassium concentration from 3.1 mEq/l to 3.5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in ameliorating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production. |
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Authors:
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Minoru Kawamura; Masahiko Owada; Jun Ino; Takashi Sugawara; Tatsuya Nakano; Izumi Mochizuki; Tsutomu Sakuma; Toshie Segawa; Itaru Motegi; Hironobu Sasano |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 42 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-14 Completed Date: 2003-10-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 507-12 Citation Subset: IM |
Affiliation:
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Department of General Internal Medicine, Iwate Prefectural Central Hospital, 1-4-1 Ueda, Morioka 020-0066. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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18-Hydroxydesoxycorticosterone
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blood,
metabolism* Adrenal Glands / pathology*, surgery* Adrenalectomy / methods* Biopsy, Needle Blood Pressure Determination Female Follow-Up Studies Humans Hyperplasia / pathology, surgery Hypertension / diagnosis Immunohistochemistry Japan Middle Aged Potassium / blood Risk Assessment Severity of Illness Index Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/18-Hydroxydesoxycorticosterone; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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