Document Detail

Effect of undernutrition and vitamin A deficiency on the phospholipid composition of rat tissues at 21 days of age. -- I. Liver, spleen and kidney.
MedLine Citation:
PMID:  6853057     Owner:  NLM     Status:  MEDLINE    
Studies were made of the effects of undernutrition and Vitamin A deficiency on the phospholipid composition of liver, spleen and kidney in rat. Undernutrition and vitamin A deficiency cause a significant deficit in body and tissue weights. But the deficit seems to be more in undernourished rats. Significant deficits were found in the concentration of total phospholipid in livers from both the experimental groups. This decrease in total phospholipid was reflected in most of the phospholipids with a significant decrease in phosphatidyl serine and inositol fraction of undernourished rats. The concentration of total phospholipid in the spleen was increased in undernourished rats. This increase was mainly confined to the sphingomyelin fraction. However the phosphatidyl choline was found to decrease in undernourished rats. No major changes were observed in the concentration of different phospholipids of kidney from the experimental rats. These results suggest that undernutrition and vitamin A deficiency have differential effects on the phospholipid composition of different tissues and the effects of vitamin A deficiency seems to be due to general growth retardation rather than the specific effect of vitamin A per se.
A Khanna; T S Reddy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  53     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1983  
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
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MeSH Terms
Body Weight
Growth Disorders / etiology
Kidney / analysis*
Liver / analysis*
Nutrition Disorders / metabolism*
Organ Size
Phospholipids / analysis*
Pregnancy Complications / metabolism
Rats, Inbred Strains
Spleen / analysis*
Vitamin A Deficiency / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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