Document Detail


Effect of ultrasound-guided radiofrequency ablation in incompletely treated hepatocellular carcinoma after transcatheter arterial chemoembolization.
MedLine Citation:
PMID:  22563280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effectiveness of ultrasound-guided radiofrequency (RF) ablation in patients with incompletely treated hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) and to evaluate possible prognostic factors for this therapy.
SUBJECTS AND METHODS: Thirty nine patients with incompletely treated single HCC (≤ 5 cm) after TACE were treated with RF ablation. All patients were evaluated for complete tumor ablation rate, local recurrence-free rate, overall survival rate, and complications. Local recurrence-free rate and overall survival rate were calculated using the Kaplan-Meier method. The possible prognostic factors of local recurrence-free rate and survival rate were analyzed using Cox proportional-hazards regression model.
RESULTS: The complete tumor ablation rate was 92.3%. Local recurrence-free rates for 1-, 2-, 3-, and 5-years were 81.7%, 63.1%, 53.6%, and 35.7%, respectively. One-, 2-, 3-, and 5-year overall survival rates were 96.9%, 82.9%, 67.8%, and 48.4%, respectively. Among prognostic factors included in the analysis, only tumor diameter (≤ 2 cm versus > 2 cm) was statistically significant in terms of predicting local recurrence. Complications were observed in two patients, one with liver abscess and the other with portal venous thrombosis.
CONCLUSION: Ultrasound-guided RF ablation could be effective and safe in treating incompletely treated HCC after TACE. The diameter of HCC was a significant prognostic factor for local recurrence.
Authors:
Nam Kyu Chang; Sang Soo Shin; Jin Woong Kim; Hyung Jun Kim; Yong Yeon Jeong; Suk Hee Heo; Jae Kyu Kim; Heoung Keun Kang
Publication Detail:
Type:  Journal Article     Date:  2012-04-23
Journal Detail:
Title:  Korean journal of radiology : official journal of the Korean Radiological Society     Volume:  13 Suppl 1     ISSN:  2005-8330     ISO Abbreviation:  Korean J Radiol     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  100956096     Medline TA:  Korean J Radiol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  S104-11     Citation Subset:  IM    
Affiliation:
Department of Radiology, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun 519-809, Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carcinoma, Hepatocellular / pathology,  therapy*,  ultrasonography
Catheter Ablation / methods*
Chemoembolization, Therapeutic / methods*
Combined Modality Therapy
Female
Humans
Liver Neoplasms / pathology,  therapy*,  ultrasonography
Male
Middle Aged
Neoplasm Recurrence, Local
Postoperative Complications
Prognosis
Proportional Hazards Models
Treatment Outcome
Ultrasonography, Interventional*
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