Document Detail


Effect of ubiquinone on exercise-induced lipid peroxidation in rat tissues.
MedLine Citation:
PMID:  9189728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in the amount of thiobarbituric acid-reactive substances (TBARS), an index of the lipid peroxidation, were estimated in liver, heart, and the red and white components of gastrocnemius muscle of control (C) and ubiquinone-treated rats (T, 10 mg.kg-1 daily, for 4 weeks) at rest, and 3 and 24 h after running until the rats were exhausted. The activity of creatine kinase in serum and the level of the non-protein sulphhydryl groups (NP-SH) in the above organs were also determined. The running time until exhaustion was longer in T than in C [83.0 (SD 13.8) vs 72.2 (SD 14.8) min, P < 0.05]. The exercise resulted in a significant increase (P < 0.01) in the TBARS amounts in all the tissues obtained from C and in the liver and heart of T. The postexercise amounts of TBARS were significantly higher (P < 0.01) in C than in T. The resting amounts of NP-SH in the heart and liver were significantly higher (P < 0.05) in C compared to T. The exercise led to a decrease in the NP-SH content in the heart and liver (P < 0.05) of C but did not seem to affect the NP-SH contents in these tissues in T. No effect of ubiquinone treatment on postexercise increase in the serum creatine kinase concentration was found. It was concluded that in rats ubiquinone treatment markedly suppresses exercise-induced lipid peroxidation in such organs as liver, heart and gastrocnemius muscle.
Authors:
J Faff; A Frankiewicz-Jóźko
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  75     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1997  
Date Detail:
Created Date:  1997-08-01     Completed Date:  1997-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  IM; S    
Affiliation:
Department of Applied Physiology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Creatine Kinase / metabolism
Lipid Peroxidation / physiology*
Liver / chemistry
Male
Muscle, Skeletal / chemistry
Myocardium / chemistry
Oxidation-Reduction
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances / metabolism*
Ubiquinone / pharmacology*
Chemical
Reg. No./Substance:
0/Thiobarbituric Acid Reactive Substances; 1339-63-5/Ubiquinone; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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