| Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery. | |
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MedLine Citation:
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PMID: 17274654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have obtained structure-activity relations for nanosphere drug delivery as a function of the chemical properties of a tunable family of self-assembling triblock copolymers. These block copolymers are synthesized with hydrophobic oligomers of a desaminotyrosyl tyrosine ester and diacid and hydrophilic poly(ethylene glycol). We have calculated the thermodynamic interaction parameters for the copolymers with anti-tumor drugs to provide an understanding of the drug binding by the nanospheres. We find that there is an optimum ester chain length, C8, for nanospheres in terms of their drug loading capacities. The nanospheres release the drugs under dialysis conditions, with release rates strongly influenced by solution pH. The nanospheres, which are themselves non-cytotoxic, deliver the hydrophobic drugs very effectively to tumor cells as measured by cell killing activity in vitro and thus offer the potential for effective parentarel in vivo delivery of many hydrophobic therapeutic agents. |
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Authors:
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Larisa Sheihet; Karolina Piotrowska; Robert A Dubin; Joachim Kohn; David Devore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-03 |
Journal Detail:
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Title: Biomacromolecules Volume: 8 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-07-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 998-1003 Citation Subset: IM |
Affiliation:
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New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, New Jersey 08854, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Drug Carriers / chemistry Drug Delivery Systems* Hydrogen-Ion Concentration Macromolecular Substances / chemistry Models, Chemical Molecular Weight Nanostructures Nanotubes / chemistry* Paclitaxel / chemistry Polyethylene Glycols / chemistry Polymers / chemistry* Structure-Activity Relationship Tyrosine / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Macromolecular Substances; 0/Polyethylene Glycols; 0/Polymers; 33069-62-4/Paclitaxel; 55520-40-6/Tyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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