Document Detail


Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery.
MedLine Citation:
PMID:  17274654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have obtained structure-activity relations for nanosphere drug delivery as a function of the chemical properties of a tunable family of self-assembling triblock copolymers. These block copolymers are synthesized with hydrophobic oligomers of a desaminotyrosyl tyrosine ester and diacid and hydrophilic poly(ethylene glycol). We have calculated the thermodynamic interaction parameters for the copolymers with anti-tumor drugs to provide an understanding of the drug binding by the nanospheres. We find that there is an optimum ester chain length, C8, for nanospheres in terms of their drug loading capacities. The nanospheres release the drugs under dialysis conditions, with release rates strongly influenced by solution pH. The nanospheres, which are themselves non-cytotoxic, deliver the hydrophobic drugs very effectively to tumor cells as measured by cell killing activity in vitro and thus offer the potential for effective parentarel in vivo delivery of many hydrophobic therapeutic agents.
Authors:
Larisa Sheihet; Karolina Piotrowska; Robert A Dubin; Joachim Kohn; David Devore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-03
Journal Detail:
Title:  Biomacromolecules     Volume:  8     ISSN:  1525-7797     ISO Abbreviation:  Biomacromolecules     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-07-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  998-1003     Citation Subset:  IM    
Affiliation:
New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, New Jersey 08854, USA.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid
Drug Carriers / chemistry
Drug Delivery Systems*
Hydrogen-Ion Concentration
Macromolecular Substances / chemistry
Models, Chemical
Molecular Weight
Nanostructures
Nanotubes / chemistry*
Paclitaxel / chemistry
Polyethylene Glycols / chemistry
Polymers / chemistry*
Structure-Activity Relationship
Tyrosine / chemistry*
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Macromolecular Substances; 0/Polyethylene Glycols; 0/Polymers; 33069-62-4/Paclitaxel; 55520-40-6/Tyrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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