Document Detail


Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants.
MedLine Citation:
PMID:  9784633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of docosahexaenoic acid (DHA) supplementation of infant formulas on fatty acid composition of blood phospholipids in term infants. Two fish oil supplemented formulas containing 0.45 wt% DHA and high (0.35%) or low (0.10%) eicosapentaenoic acid (EPA) were fed for 42 days and compared with a standard formula and breast milk. Infants fed supplemented formulas and breast milk had similar time-dependent changes for DHA from birth to day 42, i.e., slight decreases in plasma phospholipids and erythrocyte phosphatidylcholine and no change in erythrocyte phosphatidylethanolamine. Low-EPA formula prevented EPA accumulation but did not limit the significant decrease in arachidonic acid (AA) noted in infants fed high-EPA formula. These results suggest that term infant formulas should be supplemented with DHA-rich EPA, low fish oil and AA to achieve a fatty acid status in formula-fed infants similar to that of breast-fed infants.
Authors:
C Maurage; P Guesnet; M Pinault; J Rochette de Lempdes; G Durand; J Antoine; C Couet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  74     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  416-29     Citation Subset:  IM    
Affiliation:
Equipe Associée, Université de Tours EA2103-INRA, Laboratoire de Nutrition et Securité Alimentaire, Jouy-en-Josas, France.
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acid / administration & dosage
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage
Eicosapentaenoic Acid / administration & dosage
Erythrocytes / metabolism*
Fatty Acids / blood
Fatty Acids, Omega-3 / administration & dosage
Fish Oils / administration & dosage*
Gestational Age
Growth
Humans
Infant Food*
Infant, Newborn
Phospholipids / blood*
Vitamin E / blood
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Phospholipids; 1406-18-4/Vitamin E; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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