Document Detail

Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants.
MedLine Citation:
PMID:  9784633     Owner:  NLM     Status:  MEDLINE    
We studied the effect of docosahexaenoic acid (DHA) supplementation of infant formulas on fatty acid composition of blood phospholipids in term infants. Two fish oil supplemented formulas containing 0.45 wt% DHA and high (0.35%) or low (0.10%) eicosapentaenoic acid (EPA) were fed for 42 days and compared with a standard formula and breast milk. Infants fed supplemented formulas and breast milk had similar time-dependent changes for DHA from birth to day 42, i.e., slight decreases in plasma phospholipids and erythrocyte phosphatidylcholine and no change in erythrocyte phosphatidylethanolamine. Low-EPA formula prevented EPA accumulation but did not limit the significant decrease in arachidonic acid (AA) noted in infants fed high-EPA formula. These results suggest that term infant formulas should be supplemented with DHA-rich EPA, low fish oil and AA to achieve a fatty acid status in formula-fed infants similar to that of breast-fed infants.
C Maurage; P Guesnet; M Pinault; J Rochette de Lempdes; G Durand; J Antoine; C Couet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  74     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  416-29     Citation Subset:  IM    
Equipe Associée, Université de Tours EA2103-INRA, Laboratoire de Nutrition et Securité Alimentaire, Jouy-en-Josas, France.
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MeSH Terms
Arachidonic Acid / administration & dosage
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage
Eicosapentaenoic Acid / administration & dosage
Erythrocytes / metabolism*
Fatty Acids / blood
Fatty Acids, Omega-3 / administration & dosage
Fish Oils / administration & dosage*
Gestational Age
Infant Food*
Infant, Newborn
Phospholipids / blood*
Vitamin E / blood
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Phospholipids; 1406-18-4/Vitamin E; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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