Document Detail


Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial.
MedLine Citation:
PMID:  18951004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formula supplemented with docosahexaenoic acid (DHA) improves retinal function of preterm infants but the optimal dose is unknown. In a randomized controlled trial we examined the effect of increasing the DHA concentration of human milk and formula on circulating fatty acids of preterm infants. Infants born <33 weeks gestation were fed high-DHA milk (1% total fat as DHA) or standard-DHA milk (0.2-0.3% DHA) until reaching their estimated due date (EDD). Milk arachidonic acid (AA) concentration was approximately 0.5% for both groups. At EDD, erythrocyte membrane phospholipid DHA was elevated in the high-DHA group compared with standard-DHA (mean+/-SD, high-DHA 6.8+/-1.2, standard-DHA 5.2+/-0.7, p<0.0005) but AA was lower (high-DHA 14.9+/-1.3, standard-DHA 16.0+/-1.2, p<0.0005). Feeding preterm infants human milk and formula with 1% DHA raises but does not saturate erythrocyte phospholipids with DHA. Milk exceeding 1% DHA may be required to increase DHA status to levels seen in term infants.
Authors:
L G Smithers; R A Gibson; A McPhee; M Makrides
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-10-23
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  79     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2008 Sep-Nov
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Affiliation:
Women's and Children's Health Research Institute, Children Youth and Women's Health Service, North Adelaide and Flinders Medical Centre, Flinders Drive, Bedford Park, Australia, Australia.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Body Height
Body Weight
Docosahexaenoic Acids / administration & dosage*,  pharmacology
Double-Blind Method
Fatty Acids / blood*
Female
Humans
Infant Formula / administration & dosage,  chemistry
Infant, Newborn
Infant, Premature / blood*
Male
Milk, Human / chemistry
Chemical
Reg. No./Substance:
0/Fatty Acids; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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