Document Detail


Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development.
MedLine Citation:
PMID:  17194727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effect of two different intense exercise training regimens on skeletal muscle ion transport systems, performance, and metabolic response to exercise. Thirteen subjects performed either sprint training [ST; 6-s sprints (n = 6)], or speed endurance training [SET; 30-s runs approximately 130% Vo(2 max), n = 7]. Training in the SET group provoked higher (P < 0.05) plasma K(+) levels and muscle lactate/H(+) accumulation. Only in the SET group was the amount of the Na(+)/H(+) exchanger isoform 1 (31%) and Na(+)-K(+)-ATPase isoform alpha(2) (68%) elevated (P < 0.05) after training. Both groups had higher (P < 0.05) levels of Na(+)-K(+)-ATPase beta(1)-isoform and monocarboxylate transporter 1 (MCT1), but no change in MCT4 and Na(+)-K(+)-ATPase alpha(1)-isoform. Both groups had greater (P < 0.05) accumulation of lactate during exhaustive exercise and higher (P < 0.05) rates of muscle lactate decrease after exercise. The ST group improved (P < 0.05) sprint performance, whereas the SET group elevated (P < 0.05) performance during exhaustive continuous treadmill running. Improvement in the Yo-Yo intermittent recovery test was larger (P < 0.05) in the SET than ST group (29% vs. 10%). Only the SET group had a decrease (P < 0.05) in fatigue index during a repeated sprint test. In conclusion, turnover of lactate/H(+) and K(+) in muscle during exercise does affect the adaptations of some but not all related muscle ion transport proteins with training. Adaptations with training do have an effect on the metabolic response to exercise and specific improvement in work capacity.
Authors:
Magni Mohr; Peter Krustrup; Jens Jung Nielsen; Lars Nybo; Martin Krøyer Rasmussen; Carsten Juel; Jens Bangsbo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-28
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  292     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-04     Completed Date:  2007-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1594-602     Citation Subset:  IM    
Affiliation:
Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Universitetsparken 13, DK-2100 Copenhagen Ø, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Exercise / physiology*
Exercise Test
Glycogen / analysis,  metabolism
Heart Rate
Humans
Hydrogen-Ion Concentration
Lactic Acid / blood
Male
Monocarboxylic Acid Transporters / metabolism*
Muscle Fatigue / physiology*
Muscle, Skeletal / metabolism,  physiology*
Phosphocreatine / analysis,  metabolism
Physical Education and Training
Physical Endurance / physiology*
Potassium / blood,  metabolism
Running / physiology
Sodium / blood,  metabolism
Sodium-Potassium-Exchanging ATPase / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Monocarboxylic Acid Transporters; 50-21-5/Lactic Acid; 67-07-2/Phosphocreatine; 7440-09-7/Potassium; 7440-23-5/Sodium; 9005-79-2/Glycogen; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase
Comments/Corrections
Comment In:
Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1459; author reply R1460   [PMID:  17761904 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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