Document Detail

Effect of two cardiac glycosides, digitoxin and digoxin on blood lipids.
MedLine Citation:
PMID:  8744839     Owner:  NLM     Status:  MEDLINE    
Two cardiac glycosides, namely digitoxin and digoxin when treated with goat blood, were found to alter the lipid constitution as measured by their phosphorus content, fatty acid composition and malonaldehyde content. There was significant increase in the poly-unsaturated fatty acids (PUFA) and malonaldehyde contents in blood treated with these drugs. Possible correlation between the lipophilicity of the drugs and their biological activity is discussed.
H Dutta; A U De; C Sengupta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of biochemistry & biophysics     Volume:  33     ISSN:  0301-1208     ISO Abbreviation:  Indian J. Biochem. Biophys.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-10-15     Completed Date:  1996-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0310774     Medline TA:  Indian J Biochem Biophys     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
Department of Pharmaceutical Technology, Jadavpur University, Calcutta.
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MeSH Terms
Cardiotonic Agents / pharmacology*
Digitoxin / pharmacology*
Digoxin / pharmacology*
Fatty Acids, Nonesterified / blood
Fatty Acids, Unsaturated / blood
Lipids / blood*
Malondialdehyde / blood
Thiobarbituric Acid Reactive Substances / analysis
Reg. No./Substance:
0/Cardiotonic Agents; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Thiobarbituric Acid Reactive Substances; 20830-75-5/Digoxin; 542-78-9/Malondialdehyde; 71-63-6/Digitoxin

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