Document Detail

Effect of two amino acid solutions on leucine turnover in preterm infants.
MedLine Citation:
PMID:  15655314     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of two different parenteral amino acid mixtures, Trophamine and Primene, on leucine turnover in preterm infants. METHOD: Leucine kinetics were measured with [5,5,5 D3]leucine tracer in 15 infants receiving Trophamine (group 'T') (mean birth weight 1,263 g) and 22 who received Primene (group 'P') (mean birth weight 1,336 g) during two study periods, within a few hours after birth but before introduction of parenteral amino acid solution, and again at postnatal day 7. The rate of appearance of leucine was calculated from the enrichment of alpha-ketoisocaproic acid in plasma. RESULTS: There were no significant differences in leucine turnover within a few hours after birth in the two groups. In the infants who received Primene leucine turnover on day 7 was significantly lower than in those who received Trophamine (269 +/- 43 vs. 335 +/- 27, p < 0.05). Despite a higher intake of leucine in the Trophamine group (108 +/- 10 vs. 77 +/- 8, leucine released from proteins at day 7 was higher in this group compared to Primene (227 +/- 27 vs. 192 +/- 42 CONCLUSIONS: Primene administration results in lower leucine released from proteins, an estimate of protein breakdown, than Trophamine in preterm infants. Increases in whole body leucine turnover in response to administration of i.v. amino acids is influenced by the composition of the amino acid mixture. The factors responsible for this difference remain to be elucidated.
Miguel Sáenz de Pipaón; José Quero; Darcos J L Wattimena; Pieter J J Sauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-17
Journal Detail:
Title:  Biology of the neonate     Volume:  87     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-29     Completed Date:  2005-08-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel
Servicio de Neonatología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain.
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MeSH Terms
Amino Acids / administration & dosage*
Infant Food*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature / blood,  metabolism*
Infant, Small for Gestational Age / blood,  metabolism
Leucine / blood,  metabolism*,  pharmacokinetics
Parenteral Nutrition
Reg. No./Substance:
0/Amino Acids; 0/Solutions; 61-90-5/Leucine; 65072-01-7/Travasol

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