Document Detail


Effect of tubulin diffusion on polymerization of microtubules.
MedLine Citation:
PMID:  16196603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dynamics of microtubules (MT's) growing from a nucleation center is simulated with a kinetic Monte Carlo model that includes tubulin diffusion. In the limit of fast diffusion (homogeneous tubulin concentration), MT growth is synchronous and bounded. The microtubules form an aster with a monotonously decreasing long-time distribution of lengths. Slow tubulin diffusion leads to rapid dephasing in the growth dynamics, unbounded growth of some MT's, spatial inhomogeneities, and morphological change toward a morphology with bounded short MT's located in the nucleation center and unbounded long MT's with narrowly distributed lengths. The transition from unbounded to bounded growth is driven by the competition between the reaction rate of the tubulin assembly and the tubulin's diffusion rate. While the present study reports the effect of the tubulin diffusion coefficient on the transition, the results of the simulations are qualitatively comparable to the morphological and dynamical changes of centrosome-nucleated MT's from interphase to mitosis in cellular systems where the transition is regulated by the reaction rates.
Authors:
P A Deymier; Y Yang; J Hoying
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-08-19
Journal Detail:
Title:  Physical review. E, Statistical, nonlinear, and soft matter physics     Volume:  72     ISSN:  1539-3755     ISO Abbreviation:  Phys Rev E Stat Nonlin Soft Matter Phys     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101136452     Medline TA:  Phys Rev E Stat Nonlin Soft Matter Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  021906     Citation Subset:  IM    
Affiliation:
Department of Materials Science and Engineering, The University of Arizona, Tucson, Arizona 85721, USA.
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MeSH Terms
Descriptor/Qualifier:
Binding Sites
Biopolymers / chemistry*
Computer Simulation
Crystallization / methods*
Diffusion
Dimerization
Microtubules / chemistry*
Models, Biological*
Models, Chemical*
Multiprotein Complexes / chemistry
Protein Binding
Protein Conformation
Tubulin / chemistry*
Chemical
Reg. No./Substance:
0/Biopolymers; 0/Multiprotein Complexes; 0/Tubulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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