Document Detail

Effect of tryptophan-rich egg protein hydrolysate on brain tryptophan availability, stress and performance.
MedLine Citation:
PMID:  20167402     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Reduced brain serotonin function is involved in stress-related disturbances and may particularly occur under chronic stress. Although serotonin production directly depends on the availability of its plasma dietary amino acid precursor tryptophan (TRP), previously described effects of tryptophan-rich food sources on stress-related behavior are rather modest. Recently, an egg protein hydrolysate (EPH) was developed that showed a much greater effect on brain TRP availability than pure TRP and other TRP-food sources and therefore may be more effective for performance under stress. The aim of the present study was to investigate the effects of EPH compared to placebo protein on plasma amino acids, stress coping and performance in subjects with high and low chronic stress vulnerabilities.
METHODS: In a placebo-controlled, double-blind, crossover study, 17 participants with high and 18 participants with low chronic stress vulnerabilities were monitored for mood and performance under acute stress exposure either following intake of EPH or placebo.
RESULTS: EPH significantly increased plasma TRP availability for uptake into the brain, decreased depressive mood in all subjects and improved perceptual-motor and vigilance performance only in low chronic stress-vulnerable subjects.
CONCLUSIONS: The acute use of a TRP-rich egg protein hydrolysate (EPH) is an adequate method to increase plasma TRP for uptake into the brain and may be beneficial for perceptual-motor and vigilance performance in healthy volunteers.
C Rob Markus; E Verschoor; C Firk; J Kloek; C C Gerhardt
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-18
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  29     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  610-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Department of Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands.
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MeSH Terms
Amino Acids / blood,  metabolism
Brain / metabolism*
Cross-Over Studies
Depression / diet therapy
Dietary Proteins / metabolism*
Double-Blind Method
Food, Fortified*
Protein Hydrolysates / metabolism*
Psychomotor Performance
Serotonin / blood,  metabolism
Stress, Psychological*
Tryptophan / blood*,  metabolism
Reg. No./Substance:
0/Amino Acids; 0/Dietary Proteins; 0/Protein Hydrolysates; 50-67-9/Serotonin; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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