| Effect of tryptophan and nicotinamide loads on urinary excretion of RNA metabolites by bladder cancer patients. | |
| | |
MedLine Citation:
|
PMID: 142844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a comparative study of tryptophan metabolism and urinary excretion of nucleic acid derivatives (including beta-aminoisobutyric acid, 7-methylguanine, pseudouridine, and urate) in 12 male bladder cancer patients, the excretion of pseudouridine and 7-methylguanine decreased significantly after an oral dose of 2 g L-tryptophan. A similar decrease occurred after an oral nicotinamide load of 50 mg four times a day, which indicated a possible common mode of action of tryptophan and nicotinamide. No definite resolution could be made as to the causal mechanism for the observed descrase in RNA turnover. |
| | |
Authors:
|
H R Nielsen; H Wolf; R R Brown |
Related Documents
:
|
6466694 - Urinary excretion of dicarboxylic acids from patients with the zellweger syndrome. impo... 20226754 - Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with... 16452054 - Effect of acute acid loading on acid-base and calcium metabolism. 2232494 - Removal of an inorganic acid load in subjects with ketoacidosis of chronic fasting. 4025554 - Ph regulation of endogenous acid production in subjects with chronic ketoacidosis. 18960714 - The dissociation constants of alizarin fluorine blue. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of the National Cancer Institute Volume: 59 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1977 Sep |
Date Detail:
|
Created Date: 1977-10-28 Completed Date: 1977-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 855-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminoisobutyric Acids
/
urine Guanine / analogs & derivatives, urine Humans Male Niacinamide / metabolism, pharmacology* Pseudouridine / urine RNA, Neoplasm / metabolism* Tryptophan / metabolism, pharmacology* Uric Acid / urine Urinary Bladder Neoplasms / metabolism, urine* |
| Chemical | |
Reg. No./Substance:
|
0/Aminoisobutyric Acids; 0/RNA, Neoplasm; 1445-07-4/Pseudouridine; 69-93-2/Uric Acid; 73-22-3/Tryptophan; 73-40-5/Guanine; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A histochemical study of the muscles of Drosophila melanogaster.
Next Document: Effect of schizophyllan on delayed hypersensitivity in the mouse (author's transl)