| Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic patients. | |
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MedLine Citation:
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PMID: 11505046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The capacity of alcohol cues to precipitate the desire to drink may be an important determinant of relapse to alcohol use in recovering alcohol-dependent patients. This study evaluated whether attenuation of serotonin synthesis via depletion of its precursor tryptophan reduces the magnitude of cue-induced craving for alcohol in recently abstinent alcoholic individuals. METHODS: Alcohol-dependent patients (n = 16), 1 to 3 months after detoxification, who exhibited a 20% or greater increase in reported craving when presented with an alcoholic beverage, completed two additional alcohol cue-exposure test days, 1 week apart. Each cue exposure was preceded by administration of a concentrated amino acid drink that resulted in a rapid and significant decline in plasma free tryptophan (active depletion, no tryptophan supplementation) or a similar drink containing tryptophan (placebo depletion). Tests were conducted in a randomized, double-blind fashion. RESULTS: There were no significant changes in the magnitude of cue-induced craving with active tryptophan depletion compared with placebo. CONCLUSIONS: These data question the dependence of alcohol cue-induced craving in sober alcoholics on the ongoing synthesis of serotonin. |
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Authors:
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I L Petrakis; L Trevisan; N N Boutros; D Limoncelli; N L Cooney; J H Krystal |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 25 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-15 Completed Date: 2001-09-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: United States |
Other Details:
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Languages: eng Pagination: 1151-5 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Yale University, New Haven, Connecticut, USA. ismene.petrakis@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / physiopathology*, therapy* Amino Acids / administration & dosage Double-Blind Method Ethanol Humans Placebos Recurrence Serotonin / biosynthesis Solutions Tryptophan / administration & dosage, blood, deficiency* |
| Grant Support | |
ID/Acronym/Agency:
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R01-AA10107/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Placebos; 0/Solutions; 50-67-9/Serotonin; 64-17-5/Ethanol; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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