Document Detail

Effect of trimethylcolchicinic acid methyl ether d-tartrate (TMCA) on Hodgkin's and non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  798148     Owner:  NLM     Status:  MEDLINE    
Trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36351) was administered daily by mouth to 71 patients with malignant lymphomas. Partical (greater than 50%) responses were observed in eleven of 37 patients with Hodgkin's disesse, two of 22 patients with lymphocytic lymphoma, and one of two patients with mixed cell lymphoma. One complete and three partial responses were noted in nine patients with histiocytic lymphoma. Responses lasted from one to 91+ months (median: four months) and occurred in patients whose disease was resistant to alkylating agents, vinblastine, vincristine, procarbazine, prednisone or BCNU. Toxic effects included leukopenia, thrombocytopenia, nausea, diarrhea, stomatitis, alopecia and dermatitis.
D C Stolinsky; E M Jacobs; L E Irwin; T F Pajak; J R Bateman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Oncology     Volume:  33     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  1976  
Date Detail:
Created Date:  1977-04-30     Completed Date:  1977-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  151-3     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / therapeutic use
Colchicine / adverse effects,  analogs & derivatives*,  therapeutic use
Drug Interactions
Drug Therapy, Combination
Hodgkin Disease / drug therapy*
Leukopenia / chemically induced
Lymphoma / drug therapy*
Lymphoma, Large B-Cell, Diffuse / drug therapy*
Remission, Spontaneous
Thrombocytopenia / chemically induced
Time Factors
Reg. No./Substance:
0/Antineoplastic Agents; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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