Document Detail

Effect of trimebutine maleate on emptying of stomach and gallbladder and release of gut peptide following a solid meal in man.
MedLine Citation:
PMID:  8482179     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of orally administered trimebutine maleate on gastric and gallbladder emptying and on the release of gut peptide, pancreatic polypeptide (PP), and gastrin in humans for 120 min after ingestion of a solid meal. Gastric emptying was measured by a radionuclide technique. Gallbladder emptying was estimated by real-time ultrasonography. The oral administration of 200 mg of trimebutine maleate significantly shortened the lag time in starting gastric emptying (P < 0.05). Considering gallbladder emptying, trimebutine significantly inhibited the fasting emptying induced by neural reflex. Postprandially, there was a tendency toward an accelerated gallbladder emptying in the early phase. Neither the maximal percentage of gallbladder emptying nor the time of peak gallbladder emptying were affected. Trimebutine significantly blunted the post-prandial PP response in the cephalic and gastric phases, reflecting a vagal-cholinergic activity (P < 0.05). The PP response in the intestinal phase was also blunted. Gastrin release was significantly augmented only during the period of fasting after drug administration (P < 0.05). The major effect of trimebutine maleate appears to be a shortening of the lag time at the start of gastric emptying probably via its anticholinergic activity.
H Okano; S Saeki; A Inui; Y Kawai; S Ohno; S Morimoto; A Ohmoto; T Nakashima; M Miyamoto; M Okita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  38     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-02     Completed Date:  1993-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  817-23     Citation Subset:  AIM; IM    
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Administration, Oral
Eating / physiology*
Gallbladder / drug effects*,  ultrasonography
Gastric Emptying / drug effects*
Gastrins / secretion*
Pancreatic Polypeptide / secretion*
Trimebutine / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Gastrins; 39133-31-8/Trimebutine; 59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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