Document Detail


Effect of a tricyclic antidepressant and opiate antagonist on binge-eating behavior in normoweight bulimic and obese, binge-eating subjects.
MedLine Citation:
PMID:  2008865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A subset of the obese population (25-30%) has been reported to engage in binge eating at least twice weekly (bingers) and to exhibit personality traits and food attitudes similar to those of normoweight bulimic women (bulimics). Tricyclic antidepressants and opiate antagonists effectively suppress binge eating in normoweight bulimics. This 8-wk placebo-controlled, double-blind trial investigated the effect of naltrexone and imipramine on 33 obese bingers and 22 bulimics. Naltrexone (100-150 mg/d) produced a significant reduction in binge duration in bulimics (36 +/- 16%, median +/- SIQR; P = 0.02) whereas imipramine significantly reduced binge duration in obese bingers (88 +/- 31%; P = 0.02). A strong placebo effect was observed in obese bingers and, although a reduction in binge frequency occurred with both naltrexone and imipramine, it was not significantly different from the effect in placebo control subjects. We conclude that naltrexone and imipramine may be useful agents in the treatment of binge eating.
Authors:
S A Alger; M D Schwalberg; J M Bigaouette; A V Michalek; L J Howard
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  53     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-02     Completed Date:  1991-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  865-71     Citation Subset:  AIM; IM    
Affiliation:
Division of Clinical Nutrition, Albany Medical College, NY 12208.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bulimia / complications*
Double-Blind Method
Female
Humans
Hyperphagia / complications,  drug therapy*
Imipramine / therapeutic use*
Naltrexone / therapeutic use*
Obesity / complications*
beta-Endorphin / blood
Chemical
Reg. No./Substance:
16590-41-3/Naltrexone; 50-49-7/Imipramine; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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