Document Detail


Effect of treatment with gonadotropin-releasing hormone analogues on pregnancy outcome in the baboon.
MedLine Citation:
PMID:  2530116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of a gonadotropin-releasing hormone (GnRH) agonist, Zoladex (Imperial Chemical Industries, PLC, London, England), and an antagonist, Organon 30276 (Organon, Oss, Holland), on the outcome of pregnancies when administered just after implantation was examined. The antagonist, Organon 30276, was administered continuously from days 14 through 21, and the agonist, Zoladex, was injected as long-acting pellets on day 14 after conception to pregnant baboons. Maternal baboon chorionic gonadotropin and progesterone levels and sonographic measurement were made before, during, and after treatment and throughout pregnancy of control and treated animals. Two pregnant animals were treated with 3.6 mg of Zoladex; one aborted and one had a stillbirth. Another four pregnant baboons were treated with 7.2 mg of Zoladex; two aborted, one had a premature with a low-birthweight infant, and one had a normal liveborn. Organon 30276, at 50 mg, was administered to three pregnant baboons and resulted in one stillbirth, one neonatal death, and one normal liveborn. The two pregnant baboons treated with 100 mg Organon 30276 both aborted. Therefore, treatment with these GnRH analogues in very early baboon pregnancy could adversely affect the outcome of pregnancy. Thus attention should be paid to the possible presence of early pregnancy at the time of GnRH analogue therapy, which might adversely affect the outcome of the pregnancy.
Authors:
I S Kang; T J Kuehl; T M Siler-Khodr
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  52     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-18     Completed Date:  1989-12-18     Revised Date:  2008-08-30    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  846-53     Citation Subset:  IM    
Affiliation:
University of Texas Health Science Center, Department of Obstetrics and Gynecology, San Antonio 78284.
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MeSH Terms
Descriptor/Qualifier:
Animals
Buserelin / pharmacology
Chorionic Gonadotropin / blood
Female
Gonadotropin-Releasing Hormone / antagonists & inhibitors,  pharmacology
Goserelin
Pituitary Hormone-Releasing Hormones / pharmacology*
Pregnancy
Pregnancy Outcome*
Pregnancy, Animal / drug effects*
Progesterone / blood
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Pituitary Hormone-Releasing Hormones; 33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone; 57982-77-1/Buserelin; 65807-02-5/Goserelin; 83539-08-6/LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)-

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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