Document Detail

Effect of treatment of palatal inflammatory papillary hyperplasia with local and systemic antifungal agents accompanied by renewal of complete dentures.
MedLine Citation:
PMID:  8739138     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to estimate the effect of local and systemic antifungal treatment, accompanied by renewal of complete dentures, on palatal inflammatory papillary hyperplasia (PIPH). The treatment groups consisted of 26 subjects treated with a local antifungal agent (miconazole, 2% gel) for 4 weeks and 13 subjects treated with a systemic antifungal agent (fluconazole, 50 mg) for 2 weeks (test groups). Ten subjects fitted with new complete dentures served as a control group. Variables examined before antifungal and prosthetic treatment included estimation of the size and color of the affected palatal area, measurements of the lengths of the papillae, and salivary variables. Six months after the completion of prosthetic treatment healing was determined as disappearance or marked reduction of the redness of the PIPH. Healing was more often observed in test groups (64%) than in the control group (20%) (p = 0.012). Fifty-eight per cent of the subjects treated with a local (miconazole, 2%) and 77% of those treated with a systemic (fluconazole, 50 mg) antifungal agent were healed. Even though papillary hyperplastic tissue did not disappear, the treatment of PIPH with an antifungal agent without surgery before renewal of dentures might be an alternative treatment in mild cases.
M A Salonen; A M Raustia; K S Oikarinen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta odontologica Scandinavica     Volume:  54     ISSN:  0001-6357     ISO Abbreviation:  Acta Odontol. Scand.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-16     Completed Date:  1996-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370344     Medline TA:  Acta Odontol Scand     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  D; IM    
Department of Prosthetic Dentistry and Stomatognathic Physiology, University of Oulu, Finland.
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MeSH Terms
Administration, Oral
Administration, Topical
Antifungal Agents / administration & dosage*,  therapeutic use
Candidiasis, Oral / drug therapy*
Chi-Square Distribution
Denture, Complete, Upper / adverse effects*
Fluconazole / administration & dosage,  therapeutic use
Hyperplasia / etiology
Miconazole / administration & dosage,  therapeutic use
Middle Aged
Mouth Mucosa / microbiology
Stomatitis, Denture / drug therapy*,  etiology,  microbiology
Treatment Outcome
Reg. No./Substance:
0/Antifungal Agents; 22916-47-8/Miconazole; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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