Document Detail


Effect of trapidil on regional myocardial function during acute coronary occlusion in the dog.
MedLine Citation:
PMID:  7200778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of an antianginal agent, N,N-diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-7-amine (trapidil, Rocornal) (5-10 mg/kg), on regional myocardial function were studied in 17 open-chest dogs. The animals were instrumented with a micromanometer for measurement of left ventricular pressure, an electromagnetic flow probe around the left circumflex coronary artery, and 3 pairs of ultrasonic crystals in control, marginal and ischemia-induced segments. In cases of an intact coronary artery, trapidil increased peak dP/dt by 48%, heart rate by 19%, and coronary blood flow by 40%. End-diastolic segment length decreased by 7% with an increase of 17% in shortening. Coronary occlusion increased end-diastolic length of all three segments. In the ischemic segment, active shortening was rapidly replaced by systolic expansion. In the marginal segment, percent shortening decreased by 58%, while in the control segment, shortening was augmented by 11%. Trapidil administered during coronary occlusion significantly improved the shortening of control and marginal segments, as associated with a reduction in end-diastolic length. There was no significant change in function of the ischemic segment. These effects of tripidil during coronary occlusion were not blocked by propranolol (0.5-1.0 mg/kg). These data suggest that trapidil may be an effective treatment for left ventricular failure due to myocardial ischemia by virtue of its potent positive inotropic effects associated with substantial increases in myocardial blood supply sufficient to counteract the increase in oxygen consumption.
Authors:
M Takahashi; S Sasayama; M Nakamura; K Hirose; C Kawai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  32     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1982  
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  214-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Chemical Phenomena
Chemistry
Coronary Disease / drug therapy*,  physiopathology
Dogs
Female
Heart / drug effects*
Hemodynamics / drug effects
Male
Perfusion
Propranolol / pharmacology
Pyrimidines / pharmacology*
Trapidil / pharmacology*
Chemical
Reg. No./Substance:
0/Pyrimidines; 15421-84-8/Trapidil; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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