| Effect of transthoracic shocks on left ventricular function. | |
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MedLine Citation:
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PMID: 16095796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although defibrillating shocks are thought to depress ventricular function transiently, the independent effects of high strength shocks (without the metabolic sequelae of pre-shock fibrillation) have not been assessed systematically in humans. Therefore, we delivered three consecutive synchronized monophasic transthoracic shocks (200, 200 and 360 J) at 60s intervals during sinus rhythm and evaluated the effect on left ventricular chamber size and function as determined by transesophageal echocardiography in 11 patients (mean age 67+/-8 years, 9M/2F) with depressed left ventricular function (left ventricular ejection fraction: 14-37%). The shocks did not alter hemodynamics consistently. On average, the shocks did not alter stroke volume, cardiac output, left ventricular ejection fraction or regional wall thickening (all p>0.05 versus baseline). This effect was highly variable and 36% of patients experienced a >25% reduction in cardiac output by the final shock. There was a tendency for regional wall thickening to worsen in the best baseline sextant with an offsetting significant increase in thickening in the worst baseline sextant (p=0.05). Thus, repetitive defibrillation strength transthoracic shocks do not impair left ventricular function consistently in patients with cardiomyopathy. However, the effect is widely variable and potentially important depression of left ventricular function does occur in some patients. |
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Authors:
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Kenneth M Stein; Richard B Devereux; Rebecca T Hahn; Steven M Markowitz; Suneet Mittal; Sei Iwai; Bruce B Lerman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Resuscitation Volume: 66 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-02 Completed Date: 2006-02-09 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 309-15 Citation Subset: IM |
Affiliation:
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Maurice & Corinne Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA. kstein@mail.med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Output Diastole Echocardiography, Transesophageal Electric Countershock / methods* Female Humans Male Organ Size Systole Treatment Outcome Ventricular Dysfunction, Left / pathology, physiopathology*, therapy*, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL-56139/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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