Document Detail


Effect of transport and competition on ligand binding.
MedLine Citation:
PMID:  17027464     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We present a model to describe the physics of chemoreception in processes determined by competitive ligand binding. Our model describes the competition between various populations, such as ligands vs. blockers and receptors vs. decoys, in protein activation when diffusion is rate-determining. Full spatio-temporal solutions can be obtained numerically. The model structure is kept simple enough as to permit its easy generalization to describe a large subset of the manifold of possible situations occurring in nature. The power and simplicity of the proposed method are exhibited through the solution of several examples which are discussed in detail.
Authors:
C A Condat; P P Delsanto; E Ruffino; G Perego
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biophysical chemistry     Volume:  76     ISSN:  0301-4622     ISO Abbreviation:  Biophys. Chem.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2007-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403171     Medline TA:  Biophys Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-98     Citation Subset:  -    
Affiliation:
Department of Physics, University of Puerto Rico, Mayaguez, PR, USA.
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