Document Detail


Effect of transdermal nicotine administration on exercise endurance in men.
MedLine Citation:
PMID:  16627574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nicotine is widely reported to increase alertness, improve co-ordination and enhance cognitive performance; however, to our knowledge there have been no attempts to replicate these findings in relation to exercise endurance. The purpose of this study was to determine the effects nicotine might have on cycling endurance, perception of exertion and a range of physiological variables. With local ethics committee approval and having obtained informed consent, 12 healthy, non-smoking men (22 +/- 3 years; maximal O2 uptake, 56 +/- 6 ml kg(-1) min(-1), mean +/- s.d.) cycled to exhaustion at 18 degrees C and 65% of their peak aerobic power, wearing either a 7 mg transdermal nicotine patch (NIC) or a colour-matched placebo (PLA) in a randomized cross-over design; water was available ad libitum. Subjects were exercising at approximately 75% of their maximal O2 uptake with no differences in cadence between trials. Ten out of 12 subjects cycled for longer with NIC administration, and this resulted in a significant 17 +/- 7% improvement in performance (P < 0.05). No differences were observed for perceived exertion, heart rate or ventilation. There were no differences in concentrations of plasma glucose, lactate or circulating fatty acids. In the absence of any effect on peripheral markers, we conclude that nicotine prolongs endurance by a central mechanism. Possible modes of action are suggested.
Authors:
Toby Mündel; David A Jones
Related Documents :
3425334 - Tissue oxygenation in septic respiratory failure.
12133884 - Bicarbonate attenuates arterial desaturation during maximal exercise in humans.
10759604 - Endogenous nitric oxide in the control of skeletal muscle oxygen extraction during exer...
6431044 - Effect of decreased o2 affinity of hemoglobin on work performance during exercise in he...
1389734 - Influence of power and aerobic exercise training on haemostatic factors after coronary ...
22878434 - Exercise dose and mobility outcome in a comprehensive stroke unit: description and pred...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-04-20
Journal Detail:
Title:  Experimental physiology     Volume:  91     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  705-13     Citation Subset:  IM    
Affiliation:
Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. t.mundel@bham.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / drug effects,  physiology
Administration, Cutaneous
Adult
Cross-Over Studies
Exercise Test / drug effects
Humans
Male
Nicotine / administration & dosage*
Physical Endurance / drug effects*,  physiology*
Physical Exertion / drug effects*,  physiology*
Chemical
Reg. No./Substance:
54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of short-term starvation versus high-fat diet on intramyocellular triglyceride accumulation a...
Next Document:  Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and ...