| Effect of transcatheter endovascular radiation with holmium-166 on neointimal formation after balloon injury in porcine coronary artery. | |
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MedLine Citation:
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PMID: 11083197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neointimal formation in response to arterial injury is a major contributing element in restenosis after coronary balloon angioplasty and stenting. Endovascular irradiation has been reported to be effective in reducing restenosis. The purpose of this study was to investigate the effect of beta-emitting holmium-166 for the inhibition of neointimal formation in porcine coronary artery. METHODS AND RESULTS: A total of 34 pigs weighing 25 to 30 kg underwent oversized balloon injury (balloon/artery ratio, 1.3:1.4) at the proximal portion of the left anterior descending and circumflex arteries. One artery was randomly assigned to receive radiation after injury. Ho-166 was left in the balloon within the delivery catheter for a period sufficient to deliver 9 Gy and 18 Gy to a depth of 1 mm from the surface of the balloon. Four weeks later, pigs were sacrificed and hearts were perfusion-fixed, followed by histopathologic analysis and planimetry for measurement of maximal intimal thickness, intimal area, and fracture length. The coronary segment of the pigs in the control group had neointimal area of 1.18+/-0.55 mm2; the pigs in the 9-Gy group had neointimal area of 0.68+/-0.40 mm2 (P<.05 vs. control); and the pigs in the 18-Gy group had neointimal area of 0.29+/-0.12 mm2 (P<.01 vs. control). The maximal intimal thickness in the 18-Gy group (0.14+/-0.11 mm) was significantly reduced compared with the maximal intimal thickness in the control group (0.48+/-0.13 mm) (P<.01). CONCLUSIONS: Intracoronary radiation with liquid Ho-166 contained in a perfusion balloon catheter is feasible and effective in reducing neointimal formation after coronary overstretch injury in pigs. Therefore intracoronary irradiation on the injured segment may further reduce restenosis after balloon injury. |
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Authors:
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H S Kim; Y H Cho; J S Kim; Y T Oh; H J Kang; M S Chun; C W Joh; C H Park; K B Park; S J Tahk; B W Choi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 7 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 2000 Sep-Oct |
Date Detail:
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Created Date: 2001-01-22 Completed Date: 2001-02-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 478-83 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Ajou University School of Medicine, Suwon, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / pathology, radiation effects Balloon Dilatation* Coronary Disease / pathology, radiotherapy Coronary Vessels / injuries, pathology*, radiation effects Heart Catheterization Holmium / administration & dosage, therapeutic use* Radioisotopes / administration & dosage, therapeutic use* Radiotherapy Dosage Recurrence Swine Tunica Intima / pathology*, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 7440-60-0/Holmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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